Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9973963 | 0.87 | PTGS1 (0.38) | ESR2PTGS1PTGS2BRD4LMNA | |
| SCHEMBL18812499 | 0.80 | BRD4 (0.51) | ESR2PTGS1PTGS2BRD4LMNA | |
| SCHEMBL27944218 | 0.79 | PDCD1 (0.41) | PTGS1PTGS2BRD4LMNATSHR | |
| SCHEMBL28064533 | 0.79 | BRD4 (0.39) | PTGS1PTGS2BRD4ALDH1A1SMN1; SMN2 | |
| SCHEMBL10472465 | 0.78 | L3MBTL1 (0.42) | ESR2PTGS1PTGS2BRD4LMNA | |
| SCHEMBL9282940 | 0.77 | PTGS2 (0.40) | PTGS2BRD4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL27944216 | 0.77 | RAB9A (0.44) | LMNAALDH1A1SMN1; SMN2NPSR1NPC1 | |
| SCHEMBL27924771 | 0.75 | ALDH1A1 (0.38) | PTGS1PTGS2BRD4LMNATSHR | |
| SCHEMBL9277637 | 0.74 | ERN1 (0.41) | PTGS1PTGS2BRD4LMNATSHR | |
| SCHEMBL27685077 | 0.70 | SMN1; SMN2 (0.43) | PTGS1PTGS2BRD4LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157428-A1 | BROMODOMAIN INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157428-A1 | BROMODOMAIN INHIBITORS AND USES THEREOF | BRD4, BRPF3, BRDT | ESR2 2078/4885PTGS1 2282/4885PTGS2 2446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.