Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1000865 | 0.91 | ALDH1A1 (0.37) | RXFP1KIF11HSD11B1CALCRLSLC40A1 | |
| SCHEMBL999019 | 0.87 | KIF11 (0.38) | RXFP1KIF11RPS6KB1ALDH1A1CYP2D6 | |
| SCHEMBL999669 | 0.86 | PAX8 (0.39) | KIF11HSD11B1CALCRLALDH1A1CYP3A4 | |
| SCHEMBL1000821 | 0.85 | KIF11 (0.41) | RXFP1KIF11SLC40A1RPS6KB1ALDH1A1 | |
| SCHEMBL999416 | 0.84 | KIF11 (0.52) | KIF11TP53MAPT | |
| SCHEMBL999201 | 0.84 | KIF11 (0.40) | RXFP1KIF11CYP3A4CYP2D6TP53 | |
| SCHEMBL998327 | 0.84 | KIF11 (0.42) | RXFP1KIF11ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL2035529 | 0.82 | KIF11 (0.47) | KIF11TP53MAPT | |
| SCHEMBL2033145 | 0.82 | KIF11 (0.43) | RXFP1KIF11ALDH1A1HPGDCYP2D6 | |
| SCHEMBL998821 | 0.82 | KIF11 (0.56) | KIF11TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872133-B2 | Tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |