Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.37 |
| ▸ | KIT | P10721 | 4/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998170 | 0.91 | ALDH1A1 (0.38) | KIF11RPS6KB1KITAKT1CYP2D6 | |
| SCHEMBL997592 | 0.87 | RXFP1 (0.39) | KIF11RPS6KB1RXFP1CYP2D6OPRK1 | |
| SCHEMBL997834 | 0.85 | KIF11 (0.38) | KIF11RPS6KB1AKT1RXFP1ALDH1A1 | |
| SCHEMBL998327 | 0.84 | KIF11 (0.42) | KIF11RXFP1CYP2D6ALDH1A1 | |
| SCHEMBL998180 | 0.82 | KIF11 (0.52) | KIF11 | |
| SCHEMBL999201 | 0.82 | KIF11 (0.40) | KIF11RXFP1CYP2D6 | |
| SCHEMBL999416 | 0.81 | KIF11 (0.52) | KIF11 | |
| SCHEMBL2033145 | 0.81 | KIF11 (0.43) | KIF11RXFP1CYP2D6OPRK1ALDH1A1 | |
| SCHEMBL2035529 | 0.81 | KIF11 (0.47) | KIF11 | |
| SCHEMBL999207 | 0.79 | KIF11 (0.38) | KIF11RPS6KB1KITAKT1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872133-B2 | Tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |