Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | IDE | P14735 | 3/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.91 |
| ▸ | CLK1 | P49759 | 1/20 | 0.68 |
| ▸ | CCR5 | P51681 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | STAT3 | P40763 | 1/20 | 0.65 |
| ▸ | CHKA | P35790 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | DPP4 | P27487 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30060845 | 0.96 | MAPK1 (0.92) | MAPK1IDEALDH1A1CLK1CCR5 | |
| SCHEMBL19422873 | 0.95 | ALDH1A1 (1.00) | MAPK1IDEALDH1A1CLK1CCR5 | |
| SCHEMBL23362082 | 0.88 | IDE (0.79) | MAPK1IDEALDH1A1CLK1CCR5 | |
| SCHEMBL31734050 | 0.88 | IDE (0.79) | MAPK1IDEALDH1A1CLK1CCR5 | |
| SCHEMBL30060839 | 0.87 | MAPK1 (0.77) | MAPK1IDEALDH1A1CLK1CCR5 | |
| SCHEMBL30061909 | 0.86 | MAPK1 (0.75) | MAPK1IDEALDH1A1CLK1CCR5 | |
| SCHEMBL23362126 | 0.86 | MAPK1 (0.74) | MAPK1IDEALDH1A1CLK1CCR5 | |
| SCHEMBL30058852 | 0.85 | MAPK1 (0.73) | MAPK1IDEALDH1A1CLK1CCR5 | |
| SCHEMBL5639851 | 0.85 | MAPK1 (0.74) | MAPK1IDEALDH1A1CLK1CCR5 | |
| SCHEMBL5639580 | 0.85 | MAPK1 (0.74) | MAPK1IDEALDH1A1CLK1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9925251-B2 | Treatments for Mycobacterium tuberculosis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-03-27 | — | — | US | disclosed |
| US-9925251-B2 | Treatments for Mycobacterium tuberculosis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-03-27 | — | — | US | disclosed |
| US-9925251-B2 | Treatments for Mycobacterium tuberculosis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-03-27 | — | — | US | disclosed |
| US-20140243255-A1 | TREATMENTS FOR MYCOBACTERIUM TUBERCULOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2014-08-28 | — | — | US | disclosed |
| US-20140243255-A1 | TREATMENTS FOR MYCOBACTERIUM TUBERCULOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2014-08-28 | — | — | US | disclosed |
| US-20140243255-A1 | TREATMENTS FOR MYCOBACTERIUM TUBERCULOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2014-08-28 | — | — | US | disclosed |
| WO-2013059622-A1 | TREATMENTS FOR MYCOBACTERIUM TUBERCULOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-04-25 | — | — | WO | disclosed |
| WO-2013059622-A1 | TREATMENTS FOR MYCOBACTERIUM TUBERCULOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-04-25 | — | — | WO | disclosed |
| WO-2012079164-A1 | ACTIVATORS OF CYLINDRICAL PROTEASES | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243255-A1 | TREATMENTS FOR MYCOBACTERIUM TUBERCULOSIS | CLPP, LONP1, CLPX | MAPK1 2793/4885IDE 530/4885ALDH1A1 2389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.