Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9977999 | 0.78 | POLB (0.52) | POLBL3MBTL1ALDH1A1MMP8HPGD | |
| SCHEMBL9978211 | 0.78 | POLB (0.60) | POLBL3MBTL1GAAALDH1A1MMP8 | |
| SCHEMBL9978003 | 0.77 | POLB (0.59) | POLBL3MBTL1GAAMMP8HPGD | |
| SCHEMBL9978174 | 0.75 | POLB (0.60) | POLBL3MBTL1GAAALDH1A1MMP8 | |
| SCHEMBL9978171 | 0.74 | POLB (0.59) | POLBL3MBTL1GAAALDH1A1MMP8 | |
| SCHEMBL9978179 | 0.73 | MMP1 (0.58) | POLBALDH1A1MMP8SMN1; SMN2KMT2A | |
| SCHEMBL9978172 | 0.73 | POLB (0.56) | POLBL3MBTL1MMP8CYP2C9CYP2C19 | |
| SCHEMBL9977989 | 0.72 | POLB (0.53) | POLBL3MBTL1GAAALDH1A1MMP8 | |
| SCHEMBL10627832 | 0.72 | POLB (0.77) | POLBL3MBTL1GAAMMP8HPGD | |
| SCHEMBL12356333 | 0.72 | POLB (1.00) | POLBL3MBTL1GAAALDH1A1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012079164-A1 | ACTIVATORS OF CYLINDRICAL PROTEASES | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-06-21 | — | — | WO | disclosed |