Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | MMP8 | P22894 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9978003 | 0.84 | POLB (0.59) | POLBMMP8KMT2ACYP2D6CYP2C9 | |
| SCHEMBL9977989 | 0.82 | POLB (0.53) | POLBMMP8KMT2ACYP2D6CYP2C9 | |
| SCHEMBL9978174 | 0.80 | POLB (0.60) | POLBMMP8KMT2ACYP2D6CYP2C9 | |
| SCHEMBL9978171 | 0.79 | POLB (0.59) | POLBMMP8KMT2ACYP2D6CYP2C9 | |
| SCHEMBL9978049 | 0.78 | POLB (0.54) | POLBMMP8KMT2ACYP2D6CYP2C9 | |
| SCHEMBL9937870 | 0.78 | POLB (0.51) | POLBMMP8NPC1RAB9A | |
| SCHEMBL9978172 | 0.77 | POLB (0.56) | POLBMMP8KMT2ACYP2D6CYP2C9 | |
| SCHEMBL9978179 | 0.77 | MMP1 (0.58) | POLBMMP8KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL12356333 | 0.76 | POLB (1.00) | POLBMMP8KMT2ACYP2D6CYP2C9 | |
| SCHEMBL9978175 | 0.76 | ALDH1A1 (0.57) | POLBMMP8KMT2ACYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012079164-A1 | ACTIVATORS OF CYLINDRICAL PROTEASES | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-06-21 | — | — | WO | disclosed |