Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 2/20 | 0.52 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.50 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.50 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.50 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9978171 | 0.89 | POLB (0.59) | POLBCYP2C9CYP2C19ALDH1A1MMP8 | |
| SCHEMBL9978172 | 0.87 | POLB (0.56) | POLBCYP2C9CYP2C19MMP8KMT2A | |
| SCHEMBL9978179 | 0.87 | MMP1 (0.58) | POLBALDH1A1MMP8KMT2ALMNA | |
| SCHEMBL9978003 | 0.86 | POLB (0.59) | POLBCYP2C9CYP2C19MMP8KMT2A | |
| SCHEMBL9978175 | 0.86 | ALDH1A1 (0.57) | POLBCYP2C9ALDH1A1CYP1A2MMP8 | |
| SCHEMBL14227538 | 0.82 | MMP8 (0.50) | POLBCYP2C9CYP2C19ALDH1A1CYP1A2 | |
| SCHEMBL14227533 | 0.81 | CNR2 (0.57) | POLBALDH1A1MMP8KMT2ALMNA | |
| SCHEMBL9978211 | 0.80 | POLB (0.60) | POLBCYP2C9CYP2C19ALDH1A1MMP8 | |
| SCHEMBL9978216 | 0.79 | POLB (0.53) | POLBCYP2C9CYP2C19ALDH1A1CYP1A2 | |
| SCHEMBL12356333 | 0.76 | POLB (1.00) | POLBCYP2C9CYP2C19ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012079164-A1 | ACTIVATORS OF CYLINDRICAL PROTEASES | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-06-21 | — | — | WO | disclosed |