Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MMP8 | P22894 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9978174 | 0.86 | POLB (0.60) | POLBMMP8KDM4ECYP2D6CYP2C9 | |
| SCHEMBL9978172 | 0.86 | POLB (0.56) | POLBMMP8CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9978171 | 0.85 | POLB (0.59) | POLBMMP8EPHX2CYP2D6CYP2C9 | |
| SCHEMBL9978211 | 0.84 | POLB (0.60) | POLBMMP8KDM4EEPHX2CYP2D6 | |
| SCHEMBL9978179 | 0.83 | MMP1 (0.58) | POLBMMP8KMT2ASMN1; SMN2 | |
| SCHEMBL9978175 | 0.82 | ALDH1A1 (0.57) | POLBMMP8KDM4ECYP2C9KMT2A | |
| SCHEMBL14227538 | 0.79 | MMP8 (0.50) | POLBMMP8CYP2C9CYP2C19RAB9A | |
| SCHEMBL9978216 | 0.78 | POLB (0.53) | POLBMMP8CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9977989 | 0.78 | POLB (0.53) | POLBMMP8KDM4EEPHX2CYP2D6 | |
| SCHEMBL12519420 | 0.78 | CNR2 (0.55) | KDM4EKMT2AL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012079164-A1 | ACTIVATORS OF CYLINDRICAL PROTEASES | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-06-21 | — | — | WO | disclosed |