Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2673397 | 0.84 | MAPT (0.46) | GAAKMT2AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL11268815 | 0.84 | ALDH1A1 (0.45) | MEN1KMT2AL3MBTL1MAPTPPARA | |
| SCHEMBL11450832 | 0.83 | CYP3A4 (0.58) | CYP3A4CYP2C9GAAHDAC8EPHX1 | |
| SCHEMBL2672622 | 0.81 | PPARG (0.47) | CYP2C9CYP2C19MAPTPPARA | |
| SCHEMBL11458388 | 0.80 | IDO1 (0.49) | CYP3A4CYP2C9HDAC8EPHX1NR4A2 | |
| SCHEMBL2672604 | 0.79 | PNMT (0.48) | MAPTPPARA | |
| SCHEMBL2685750 | 0.78 | IDO1 (0.47) | CYP3A4CYP2C9GAAHDAC8EPHX1 | |
| SCHEMBL2685745 | 0.78 | IDO1 (0.47) | CYP3A4CYP2C9GAAHDAC8EPHX1 | |
| SCHEMBL9978726 | 0.77 | CYP3A4 (0.61) | CYP3A4CYP2C9GAAHDAC8EPHX1 | |
| SCHEMBL28322156 | 0.77 | HDAC8 (0.47) | CYP3A4CYP2C9GAAHDAC8EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576515-B1 | Pyrazolecarboxamide derivatives and their use as microbiocides | SYNGENTA PARTICIPATIONS AG (CH) | 2014-04-16 | — | — | EP | disclosed |
| US-8552049-B2 | Pyrazolecarboxamide derivatives and their use as microbiocides | Syngenta Corp Protection, LLC (US) | 2013-10-08 | — | — | US | disclosed |
| EP-2576515-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | Syngenta Participations AG (CH) | 2013-04-10 | — | — | EP | disclosed |
| US-20130072535-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-03-21 | — | — | US | disclosed |
| WO-2011147690-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072535-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | HRH4, MRGPRX4, C3AR1 | CYP3A4 361/4885CYP2C9 743/4885GAA 4574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.