Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 4/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11266070 | 0.86 | ALDH1A1 (0.42) | ALDH1A1LMNANPSR1MAPTTDP1 | |
| SCHEMBL28800156 | 0.85 | ALDH1A1 (0.47) | ALDH1A1LMNANPSR1MAPTTDP1 | |
| SCHEMBL11017578 | 0.84 | LDHA (0.55) | ALDH1A1LMNANPSR1MAPTTDP1 | |
| SCHEMBL9978729 | 0.84 | CYP3A4 (0.46) | LMNAMAPTL3MBTL1PPARAMEN1 | |
| SCHEMBL2673224 | 0.82 | ALDH1A1 (0.46) | ALDH1A1MAPTHTTPPARATSHR | |
| SCHEMBL1186888 | 0.79 | ALDH1A1 (0.52) | ALDH1A1LMNANPSR1HTTTSHR | |
| SCHEMBL27700419 | 0.79 | ADRB2 (0.48) | ALDH1A1LMNANPSR1MAPTTDP1 | |
| SCHEMBL2672622 | 0.78 | PPARG (0.47) | MAPTLDHAPPARAPPARG | |
| SCHEMBL2672604 | 0.76 | PNMT (0.48) | ALDH1A1MAPTPPARAPPARG | |
| SCHEMBL2673397 | 0.76 | MAPT (0.46) | ALDH1A1LMNAMAPTL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337267-A | HYPOKETONEMIC, HYPOGLYCEMIC, ANTIDIABETIC | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-06-29 | — | — | US | disclosed |
| US-4324796-A | HYPOGLYCEMIC AGENTS, HYPOKETONEMIC AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1982-04-13 | — | — | US | disclosed |