Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Dalfampridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA1 known ✓ | Q09470 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | ASIC3 | Q9UHC3 | 3/20 | 0.57 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | CCR8 | P51685 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL314105 | 0.90 | ASIC3 (0.67) | MAPTCHRM1MEN1ALDH1A1LMNA | |
| SCHEMBL9132100 | 0.87 | ASIC3 (0.64) | MAPTCHRM1MEN1ALDH1A1LMNA | |
| SCHEMBL9151109 | 0.87 | ASIC3 (0.64) | MAPTCHRM1MEN1ALDH1A1LMNA | |
| SCHEMBL9132675 | 0.87 | ASIC3 (0.64) | MAPTCHRM1MEN1ALDH1A1LMNA | |
| SCHEMBL18745790 | 0.86 | ASIC3 (0.70) | MAPTCHRM1MEN1ALDH1A1LMNA | |
| SCHEMBL31215173 | 0.81 | ASIC3 (0.57) | MAPTCHRM1MEN1ALDH1A1LMNA | |
| SCHEMBL30173828 | 0.81 | ASIC3 (0.57) | MAPTCHRM1MEN1ALDH1A1LMNA | |
| SCHEMBL4361201 | 0.81 | ASIC3 (0.57) | MAPTCHRM1MEN1ALDH1A1LMNA | |
| SCHEMBL28996013 | 0.80 | ASIC3 (0.52) | MAPTCHRM1MEN1ALDH1A1LMNA | |
| SCHEMBL27675974 | 0.79 | ASIC3 (0.73) | MAPTCHRM1MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8083924-B2 | Small volume in vitro analyte sensor and methods of making | ABBOTT DIABETES CARE INC. (US) | 2011-12-27 | — | — | US | disclosed |