Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 1/20 | 0.51 |
| ▸ | CCR1 | P32246 | 1/20 | 0.51 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.33 |
| ▸ | FEN1 | P39748 | 2/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15085016 | 0.85 | KCNE1 (0.69) | KCNE1CCR1KCNQ1ERCC1FEN1 | |
| SCHEMBL6649904 | 0.84 | RIPK1 (0.40) | RAB9ARIPK1ERCC1FEN1ERCC4 | |
| SCHEMBL5201900 | 0.81 | MAPT (0.43) | KCNE1CCR1KCNQ1RAB9AERCC1 | |
| SCHEMBL6651415 | 0.78 | RIPK1 (0.43) | RAB9ARIPK1ERCC1FEN1ERCC4 | |
| SCHEMBL15085010 | 0.78 | KCNE1 (0.42) | KCNE1CCR1KCNQ1 | |
| SCHEMBL22400287 | 0.78 | KCNE1 (0.42) | KCNE1CCR1KCNQ1ERCC1FEN1 | |
| SCHEMBL15069797 | 0.77 | KCNE1 (0.41) | KCNE1CCR1KCNQ1ERCC1FEN1 | |
| SCHEMBL21045731 | 0.77 | KCNE1 (0.59) | KCNE1CCR1KCNQ1ERCC1FEN1 | |
| SCHEMBL5316857 | 0.71 | RIPK1 (0.36) | RAB9ARIPK1ERCC1FEN1ERCC4 | |
| SCHEMBL16445001 | 0.70 | RNASEH1 (0.38) | KCNE1CCR1KCNQ1ERCC1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2934482-A1 | GASTRO-RETENTIVE FORMULATIONS | Merck Sharp & Dohme Corp. (US) | 2015-10-28 | — | — | EP | disclosed |
| EP-2875024-A1 | HIV TREATMENT WITH AMIDO-SUBSTITUTED PYRIMIDINONE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2015-05-27 | — | — | EP | disclosed |
| WO-2014100077-A1 | GASTRO-RETENTIVE FORMULATIONS | MERCK SHARP & DOHME CORP. (US) | 2014-06-26 | — | — | WO | disclosed |
| EP-2694497-A1 | NOVEL SALTS OF RALTEGRAVIR | Lupin Limited (IN) | 2014-02-12 | — | — | EP | disclosed |
| WO-2014014933-A1 | HIV TREATMENT WITH AMIDO-SUBSTITUTED PYRIMIDINONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2014-01-23 | — | — | WO | disclosed |
| EP-2575465-A1 | SALTS OF RALTEGRAVIR | Hetero Research Foundation (IN) | 2013-04-10 | — | — | EP | disclosed |
| WO-2012137142-A1 | NOVEL SALTS OF RALTEGRAVIR | LUPIN LIMITED (IN) | 2012-10-11 | — | — | WO | disclosed |
| WO-2011148381-A1 | SALTS OF RALTEGRAVIR | HETERO RESEARCH FOUNDATION (IN) | 2011-12-01 | — | — | WO | disclosed |