Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 14/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 14/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 13/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 13/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 13/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 12/20 | 0.56 |
| ▸ | GABRA6 | Q16445 | 11/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | GABRE | P78334 | 1/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3700486 | 0.81 | GABRG2 (0.46) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL163615 | 0.81 | GABRG2 (0.46) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL29563011 | 0.81 | GABRG2 (0.46) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL13105640 | 0.81 | GABRG2 (0.46) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL2490793 | 0.81 | ALDH1A1 (0.50) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL724883 | 0.80 | ALDH1A1 (0.50) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL728168 | 0.80 | GABRG2 (0.48) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL15114586 | 0.80 | KDM4E (0.56) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL3882564 | 0.80 | GABRG2 (0.45) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL14595539 | 0.80 | GABRG2 (0.43) | GABRG2GABRB3GABRA5GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324389-B2 | Solid forms of a Raf kinase inhibitor | NOVARTIS AG (CH) | 2012-12-04 | — | — | US | disclosed |
| US-8202998-B2 | Salts of benzimidazolyl pyridyl ethers and formulations thereof | NOVARTIS AG (CH) | 2012-06-19 | — | — | US | disclosed |
| US-20100209418-A1 | Solid Forms of a Raf Kinase Inhibitor | NOVARTIS AG (CH) | 2010-08-19 | — | — | US | disclosed |
| US-20100168060-A1 | SALTS OF BENZIMIDAZOLYL PYRIDYL ETHERS AND FORMULATIONS THEREOF | NOVARTIS AG (CH) | 2010-07-01 | — | — | US | disclosed |
| US-7732465-B2 | Substituted benzimidazoles and methods of their use | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-06-08 | — | — | US | disclosed |
| US-20090170904-A1 | Substituted benzimidazoles and methods of their use | NOVARTIS AG | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100209418-A1 | Solid Forms of a Raf Kinase Inhibitor | BRAF, RAF1, ARAF | GABRG2 2878/4885GABRB3 3220/4885GABRA5 3782/4885 |
| US-20100168060-A1 | SALTS OF BENZIMIDAZOLYL PYRIDYL ETHERS AND FORMULATIONS THEREOF | PIR, BRD8, PHOSPHO1 | GABRG2 434/4885GABRB3 1003/4885GABRA5 262/4885 |
| US-20090170904-A1 | Substituted benzimidazoles and methods of their use | BRAF, DSTYK, CHEK2 | GABRG2 759/4885GABRB3 609/4885GABRA5 803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.