Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 13/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 13/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 12/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 12/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 11/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 10/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.48 |
| ▸ | GABRD | O14764 | 1/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | GABRE | P78334 | 1/20 | 0.48 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.48 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.48 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13105640 | 0.81 | GABRG2 (0.46) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL163615 | 0.81 | GABRG2 (0.46) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL29563011 | 0.81 | GABRG2 (0.46) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL3700486 | 0.81 | GABRG2 (0.46) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL724883 | 0.80 | ALDH1A1 (0.50) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL9979936 | 0.80 | GABRG2 (0.56) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL3882564 | 0.80 | GABRG2 (0.45) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL15114586 | 0.80 | KDM4E (0.56) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL31364143 | 0.79 | FTO (0.61) | GABRG2GABRB3GABRA1GABRA2GABRA5 | |
| SCHEMBL16976879 | 0.77 | CYP1A2 (0.50) | GABRG2GABRB3GABRA1GABRA2GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003544-A1 | PROTEIN KINASE INHIBITORS AND METHODS OF TREATMENT | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2012-01-12 | — | — | WO | disclosed |