SCHEMBL9979996

SCHEMBL9979996

O=C(Nc1cccc(C(=O)N2CCN3CCCC3C2)c1O)Nc1cccc(Cl)c1Cl

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CACNA1H O95180 3/20 0.49
CXCR2 P25025 6/20 0.46
MGLL Q99685 5/20 0.45
MAPK14 Q16539 1/20 0.43
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30515712 1.00 CACNA1H (0.49) CACNA1HCXCR2MGLLMAPK14KDM4E
SCHEMBL9980054 0.90 CXCR2 (0.56) CACNA1HCXCR2
SCHEMBL9980078 0.90 CXCR2 (0.56) CACNA1HCXCR2
SCHEMBL19351489 0.89 CACNA1H (0.48) CACNA1HMGLLMAPK14KDM4EALDH1A1
SCHEMBL20817497 0.88 CXCR2 (0.48) CACNA1HCXCR2MGLL
SCHEMBL9980051 0.85 L3MBTL3 (0.47) CACNA1HCXCR2MGLLKDM4EALDH1A1
SCHEMBL14329380 0.85 L3MBTL3 (0.47) CACNA1HCXCR2MGLLKDM4EALDH1A1
SCHEMBL9980080 0.85 L3MBTL3 (0.47) CACNA1HCXCR2MGLLKDM4EALDH1A1
SCHEMBL9980083 0.83 MAPK14 (0.48) CXCR2MAPK14KDM4EALDH1A1LMNA
SCHEMBL9979998 0.83 CYP1A2 (0.50) CACNA1HCXCR2MGLLKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF ARISTEA THERAPEUTICS, INC. 2023-07-06 US disclosed
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF ARISTEA THERAPEUTICS, INC. 2023-07-06 US disclosed
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF ARISTEA THERAPEUTICS, INC. 2023-07-06 US disclosed
US-10772886-B2 CXCR-2 inhibitors for treating crystal arthropathy disorders ARDEA BIOSCIENCES, INC. (US) 2020-09-15 US disclosed
US-10772886-B2 CXCR-2 inhibitors for treating crystal arthropathy disorders ARDEA BIOSCIENCES, INC. (US) 2020-09-15 US disclosed
US-20200281878-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2020-09-10 US disclosed
US-20200281878-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2020-09-10 US disclosed
US-20180235964-A1 CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-23 US disclosed
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-09 US disclosed
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-09 US disclosed
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS ARDEA BIOSCIENCES, INC. 2018-08-09 US disclosed
EP-2651891-B1 BICYCLIC RING SYSTEM SUBSTITUTED AMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS BOEHRINGER INGELHEIM INT (DE) 2016-07-13 EP disclosed
US-8648118-B2 Bicyclic ring system substituted amide functionalised phenols as medicaments BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-02-11 US disclosed
US-8648118-B2 Bicyclic ring system substituted amide functionalised phenols as medicaments BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-02-11 US disclosed
US-20120329773-A1 BICYCLIC RING SYSTEM SUBSTITUTED AMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-12-27 US disclosed
US-20120329773-A1 BICYCLIC RING SYSTEM SUBSTITUTED AMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-12-27 US disclosed
WO-2012080456-A1 BICYCLIC RING SYSTEM SUBSTITUTED AMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-06-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180235964-A1 CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS CXCR1, CXCR2, CXCR6 CACNA1H 3827/4885CXCR2 2/4885MGLL 2290/4885
US-20180221312-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS CXCR1, CXCR2, CXCR6 CACNA1H 4102/4885CXCR2 2/4885MGLL 3347/4885
US-10772886-B2 CXCR-2 inhibitors for treating crystal arthropathy disorders CXCR1, CXCR2, CXCR6 CACNA1H 3933/4885CXCR2 2/4885MGLL 2065/4885
US-20230210792-A1 USE OF A COMBINATION OF COLCHICINE AND A CXCR-2 INHIBITORS FOR THE TREATMENT OR PREVENTION OF FAMILIAL MEDITERRANEAN FEVER (FMF) AND FLARE-UPS THEREOF CXCR1, CXCR2, FPR2 CACNA1H 1364/4885CXCR2 2/4885MGLL 2308/4885
US-20120329773-A1 BICYCLIC RING SYSTEM SUBSTITUTED AMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS CXCR2, CCR2, CCR1 CACNA1H 4586/4885CXCR2 1/4885MGLL 2921/4885
US-20200281878-A1 CXCR-2 INHIBITORS FOR TREATING DISORDERS CXCR1, CXCR2, CXCR6 CACNA1H 4102/4885CXCR2 2/4885MGLL 3347/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.