Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 5/20 | 0.40 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.40 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.39 |
| ▸ | STK16 | O75716 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980391 | 0.90 | EGFR (0.41) | SRCEGFRABL1ERBB2MET | |
| SCHEMBL9980404 | 0.68 | STK4 (0.39) | SRCEGFRBRAFTNNI3KNUAK1 | |
| SCHEMBL1809126 | 0.68 | SRC (0.43) | SRCEGFRKDRBRAFTNNI3K | |
| SCHEMBL9980448 | 0.67 | LRRK2 (0.42) | SRCEGFRABL1BRAFTNNI3K | |
| SCHEMBL2225236 | 0.67 | TNNI3K (0.51) | EGFRTNNI3KTYK2CA1CA2 | |
| SCHEMBL2227348 | 0.66 | JAK2 (0.45) | SRCEGFRCSF1RTYK2TBK1 | |
| SCHEMBL9980436 | 0.66 | TNNI3K (0.37) | EGFRBRAFTNNI3KCA1CA2 | |
| SCHEMBL9980493 | 0.64 | TNNI3K (0.36) | EGFRBRAFTNNI3KCA1CA2 | |
| SCHEMBL9980424 | 0.63 | TNNI3K (0.35) | EGFRERBB2BRAFTNNI3KCA1 | |
| SCHEMBL1806924 | 0.60 | MAPK1 (0.52) | EGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |