Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 5/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980448 | 0.84 | LRRK2 (0.42) | STK4STK3EGFRBRAFTNNI3K | |
| SCHEMBL9980383 | 0.81 | LMNA (0.41) | MAPTMAPK1THRBADORA2AADORA2B | |
| SCHEMBL9980405 | 0.79 | CCNB2 (0.34) | MAPTTHRBADORA2AADORA2BADORA1 | |
| SCHEMBL12066374 | 0.78 | TNNI3K (0.64) | STK4STK3BRAFTNNI3KALDH1A1 | |
| SCHEMBL9980436 | 0.74 | TNNI3K (0.37) | EGFRBRAFTNNI3KKMT2A | |
| SCHEMBL9980486 | 0.73 | FFAR2 (0.33) | MEN1MAPTKMT2AMAPK1ALDH1A1 | |
| SCHEMBL9980493 | 0.73 | TNNI3K (0.36) | EGFRBRAFTNNI3KALDH1A1LRRK2 | |
| SCHEMBL1809126 | 0.73 | SRC (0.43) | EGFRBRAFTNNI3KKMT2AGAA | |
| SCHEMBL9980424 | 0.71 | TNNI3K (0.35) | EGFRBRAFTNNI3KLRRK2LMNA | |
| SCHEMBL9980423 | 0.68 | SRC (0.41) | EGFRBRAFTNNI3KALDH1A1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |