Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2105872 | 0.97 | NPC1 (0.46) | NPC1RAB9AKDM4ELMNAHTT | |
| SCHEMBL25481646 | 0.96 | NPC1 (0.43) | NPC1RAB9AKDM4ELMNAHTT | |
| SCHEMBL17956031 | 0.94 | KDM1A (0.43) | MAPK14MDM2 | |
| SCHEMBL18136063 | 0.90 | GPR52 (0.42) | MDM2 | |
| SCHEMBL17956061 | 0.90 | NPC1 (0.52) | NPC1RAB9AKDM4ELMNAHTT | |
| SCHEMBL17955921 | 0.89 | MAOB (0.45) | NPC1RAB9AKDM4ELMNAHTT | |
| SCHEMBL9980465 | 0.89 | KDM4E (0.47) | KDM4ELMNAHTTTP53TDP1 | |
| SCHEMBL17955897 | 0.88 | AKR1C3 (0.46) | NPC1RAB9AKDM4ELMNAHTT | |
| SCHEMBL17955991 | 0.88 | DRD2 (0.46) | KDM4ELMNAHTTTDP1AKR1C3 | |
| SCHEMBL17956037 | 0.88 | KDM4E (0.41) | KDM4ELMNAHTTTP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163791-B2 | Imidazole derivatives that induce apoptosis and their therapeutic uses | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2012-04-24 | — | — | US | disclosed |