Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | RXRG | P48443 | 2/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17955991 | 0.91 | DRD2 (0.46) | KDM4ETDP1MDM2RXRARXRB | |
| SCHEMBL2105872 | 0.91 | NPC1 (0.46) | KDM4ETDP1MDM2RXRARXRB | |
| SCHEMBL17956009 | 0.90 | AKR1C3 (0.44) | KDM4ETDP1MDM2PTGER4AKR1C3 | |
| SCHEMBL17955990 | 0.90 | RXRA (0.48) | KDM4ETDP1MDM2RXRARXRB | |
| SCHEMBL17955939 | 0.90 | HDAC1 (0.47) | MDM2AKR1C3 | |
| SCHEMBL17955897 | 0.90 | AKR1C3 (0.46) | KDM4ETDP1MDM2PTGER4AKR1C3 | |
| SCHEMBL9980441 | 0.89 | NPC1 (0.44) | KDM4ETDP1MDM2AKR1C3ALDH1A1 | |
| SCHEMBL17955923 | 0.88 | KDM4E (0.41) | KDM4ETDP1MDM2AKR1C3ALDH1A1 | |
| SCHEMBL17956037 | 0.88 | KDM4E (0.41) | KDM4ETDP1MDM2AKR1C3ALDH1A1 | |
| SCHEMBL17955965 | 0.87 | KDM4E (0.46) | KDM4ETDP1MDM2RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120040436-A | Chimeric body for degrading GPX4 based on HSP70 protein targeting, preparation method and application | 中国科学院基础医学与肿瘤研究所(筹) | 2025-05-27 | — | — | CN | disclosed |
| CN-119285649-A | Heterobifunctional compound based on HSP70 targeted degradation of BRD4, preparation and application | 中国药科大学 | 2025-01-10 | — | — | CN | disclosed |
| EP-3050875-B1 | NOVEL IMIDAZOLE DERIVATIVE AND THERAPEUTICAL USE THEREOF | UNIV YONSEI IACF (KR) | 2019-03-13 | — | — | EP | disclosed |
| US-20160297768-A1 | NOVEL IMIDAZOLE DERIVATIVES AND THERAPEUTIC USE THEREOF | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2016-10-13 | — | — | US | disclosed |
| EP-3050875-A1 | NOVEL IMIDAZOLE DERIVATIVE AND THERAPEUTICAL USE THEREOF | Industry-Academic Cooperation Foundation, Yonsei University (KR) | 2016-08-03 | — | — | EP | disclosed |
| US-8163791-B2 | Imidazole derivatives that induce apoptosis and their therapeutic uses | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2012-04-24 | — | — | US | disclosed |
| US-8163791-B2 | Imidazole derivatives that induce apoptosis and their therapeutic uses | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2012-04-24 | — | — | US | disclosed |
| US-20100105726-A1 | IMIDAZOLE DERIVATIVES THAT INDUCE APOPTOSIS AND THEIR THERAPEUTIC USES | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2010-04-29 | — | — | US | disclosed |
| US-20100105726-A1 | IMIDAZOLE DERIVATIVES THAT INDUCE APOPTOSIS AND THEIR THERAPEUTIC USES | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105726-A1 | IMIDAZOLE DERIVATIVES THAT INDUCE APOPTOSIS AND THEIR THERAPEUTIC USES | NFATC1, AIFM1, TP53 | KDM4E 3985/4885TDP1 1002/4885MDM2 411/4885 |
| US-20160297768-A1 | NOVEL IMIDAZOLE DERIVATIVES AND THERAPEUTIC USE THEREOF | TP53, BAD, API5 | KDM4E 1678/4885TDP1 668/4885MDM2 590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.