Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 8/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3174451 | 0.80 | ADORA3 (0.48) | ADORA3ADORA2AADORA1KMT2APOLB | |
| SCHEMBL5786452 | 0.80 | ADORA3 (0.46) | SGK1ADORA3ADORA2AADORA1RAB9A | |
| SCHEMBL13655439 | 0.75 | KMT2A (0.63) | ADORA3ADORA2AADORA1RAB9AKMT2A | |
| SCHEMBL7888421 | 0.72 | CHEK1 (0.40) | SGK1SMN1; SMN2ALDH1A1HTTXDH | |
| SCHEMBL3762000 | 0.72 | HPGDS (0.47) | ADORA3ADORA2AADORA1RAB9AKMT2A | |
| SCHEMBL422358 | 0.71 | PDE10A (0.61) | RAB9AKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL10083704 | 0.69 | L3MBTL1 (0.62) | ADORA3ADORA2AADORA1RAB9AKMT2A | |
| SCHEMBL14570604 | 0.69 | ADORA2A (0.47) | SGK1ADORA3ADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL61883 | 0.69 | PLK4 (0.53) | SGK1ADORA3ADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL19169418 | 0.68 | PDE10A (0.60) | RAB9AKMT2ASMN1; SMN2ALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076338-B2 | Such as 6-(4-phenylpiperazin-1-yl)-9H-purine; cell proliferation/differentiation | EXELIXIS, INC. (US) | 2011-12-13 | — | — | US | disclosed |