SCHEMBL9983240

SCHEMBL9983240

CCSc1nc(=O)[nH]c(=O)n1Cc1ccc(Cl)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.55
GNRHR P30968 1/20 0.47
P2RX3 P56373 4/20 0.47
ATM Q13315 1/20 0.46
APOBEC3G Q9HC16 1/20 0.46
HSD17B10 Q99714 2/20 0.46
MAPT P10636 2/20 0.46
KDM1A O60341 1/20 0.46
BRD4 O60885 1/20 0.45
BRD2 P25440 1/20 0.45
BRD3 Q15059 1/20 0.45
BRDT Q58F21 1/20 0.45
HTT P42858 2/20 0.45
LMNA P02545 1/20 0.45
ALDH1A1 P00352 4/20 0.45
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
HPGD P15428 2/20 0.45
MAPK1 P28482 1/20 0.45
TP53 P04637 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9983147 0.86 ATM (0.60) TSHRP2RX3ATMAPOBEC3GBRD4
SCHEMBL12045850 0.79 P2RX3 (0.52) P2RX3ATMAPOBEC3GHSD17B10BRD4
SCHEMBL29989784 0.78 LMNA (0.53) P2RX3ATMAPOBEC3GBRD4BRD2
SCHEMBL15039615 0.76 TSHR (0.58) TSHRP2RX3TP53
SCHEMBL14900210 0.76 BRAF (0.47) TSHRP2RX3ATMAPOBEC3GMAPT
SCHEMBL15015797 0.75 TSHR (0.55) TSHRGNRHRP2RX3ATMAPOBEC3G
SCHEMBL15039711 0.75 TSHR (0.57) TSHRGNRHRP2RX3MAPTHTT
SCHEMBL14725062 0.74 BRAF (0.48) P2RX3ATMAPOBEC3GMAPTHTT
SCHEMBL15015852 0.74 TSHR (0.56) TSHRGNRHRP2RX3MAPTHTT
SCHEMBL9983069 0.73 P2RX3 (0.57) TSHRP2RX3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630525-B2 Triazinylmethylcycloalkylcarboxylic acid derivative, and pharmaceutical composition and use thereof SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) 2026-05-19 US disclosed
WO-2024114663-A9 CRYSTAL FORM OF TRIAZINYL METHYL CYCLOALKYL CARBOXYLIC ACID DERIVATIVE AND USE THEREOF 上海海雁医药科技有限公司 2024-07-18 WO disclosed
WO-2024114663-A1 CRYSTAL FORM OF TRIAZINYL METHYL CYCLOALKYL CARBOXYLIC ACID DERIVATIVE AND USE THEREOF 上海海雁医药科技有限公司 2024-06-06 WO disclosed
EP-4349816-A1 TRIAZINYLMETHYLCYCLOALKYLCARBOXYLIC ACID DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) 2024-04-10 EP disclosed
CN-117425643-A Triazinylmethyl cycloalkyl carboxylic acid derivatives, pharmaceutical compositions and uses thereof 上海海雁医药科技有限公司 2024-01-19 CN disclosed
WO-2022253270-A1 TRIAZINYLMETHYLCYCLOALKYLCARBOXYLIC ACID DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 上海海雁医药科技有限公司 2022-12-08 WO disclosed
US-10065941-B2 Aminotriazine derivative and pharmaceutical composition comprising the same SHIONOGI & CO., LTD. (JP) 2018-09-04 US disclosed
EP-3009432-B1 AMINO-TRIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAID DERIVATIVES SHIONOGI & CO (JP) 2018-04-25 EP disclosed
US-20170362199-A1 AMINOTRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME SHIONOGI & CO., LTD. (JP) 2017-12-21 US disclosed
US-20170362199-A1 AMINOTRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME SHIONOGI & CO., LTD. (JP) 2017-12-21 US disclosed
US-9150546-B2 Triazine derivative and pharmaceutical composition comprising the same SHIONOGI & CO., LTD. (JP) 2015-10-06 US disclosed
US-9150546-B2 Triazine derivative and pharmaceutical composition comprising the same SHIONOGI & CO., LTD. (JP) 2015-10-06 US disclosed
US-20130172317-A1 TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION HAVING AN ANALGESIC ACTIVITY COMPRISING THE SAME SHIONOGI & CO., LTD. (JP) 2013-07-04 US disclosed
US-20130172317-A1 TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION HAVING AN ANALGESIC ACTIVITY COMPRISING THE SAME SHIONOGI & CO., LTD. (JP) 2013-07-04 US disclosed
EP-2604595-A1 TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOUND THAT CONTAINS SAME AND EXHIBITS ANALGESIC ACTIVITY Shionogi&Co., Ltd. (JP) 2013-06-19 EP disclosed
EP-2604595-A1 TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOUND THAT CONTAINS SAME AND EXHIBITS ANALGESIC ACTIVITY Shionogi&Co., Ltd. (JP) 2013-06-19 EP disclosed
WO-2012020749-A1 TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOUND THAT CONTAINS SAME AND EXHIBITS ANALGESIC ACTIVITY 塩野義製薬株式会社 (JP) 2012-02-16 WO disclosed
US-20110319414-A1 NOVEL TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME SHIONOGI & CO., LTD. (JP) 2011-12-29 US disclosed
US-20110319414-A1 NOVEL TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME SHIONOGI & CO., LTD. (JP) 2011-12-29 US disclosed
EP-2399910-A1 NOVEL TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME Shionogi&Co., Ltd. (JP) 2011-12-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10065941-B2 Aminotriazine derivative and pharmaceutical composition comprising the same P2RX3, P2RX2, P2RX1 TSHR 216/4885GNRHR 1112/4885P2RX3 1/4885
US-20110319414-A1 NOVEL TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME P2RX3, P2RX5, P2RX2 TSHR 171/4885GNRHR 416/4885P2RX3 1/4885
US-20130172317-A1 TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION HAVING AN ANALGESIC ACTIVITY COMPRISING THE SAME P2RX3, P2RX4, P2RX2 TSHR 527/4885GNRHR 552/4885P2RX3 1/4885
US-12630525-B2 Triazinylmethylcycloalkylcarboxylic acid derivative, and pharmaceutical composition and use thereof P2RX3, P2RX1, P2RX2 TSHR 762/4885GNRHR 1331/4885P2RX3 1/4885
US-20170362199-A1 AMINOTRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME P2RX3, P2RX2, P2RX1 TSHR 216/4885GNRHR 1112/4885P2RX3 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.