Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9982859 | 0.82 | MAPK1 (0.48) | MAPK1MAPTLMNAPKMRAB9A | |
| SCHEMBL9982465 | 0.75 | MAPT (0.55) | MAPK1MAPTLMNAPKMRAB9A | |
| SCHEMBL16407599 | 0.71 | MAPK1 (0.60) | MAPK1MAPTLMNAPKMRAB9A | |
| SCHEMBL4910166 | 0.71 | LMNA (0.63) | MAPK1MAPTLMNAKMT2AMEN1 | |
| SCHEMBL13547430 | 0.71 | MAPK1 (0.66) | MAPK1MAPTPKMRAB9AKMT2A | |
| SCHEMBL3992139 | 0.70 | MAPK1 (0.65) | MAPK1MAPTPKMRAB9AKMT2A | |
| SCHEMBL3992132 | 0.70 | MAPK1 (0.65) | MAPK1MAPTPKMRAB9AKMT2A | |
| SCHEMBL22588060 | 0.70 | MAPK1 (0.73) | MAPK1MAPTLMNAPKMRAB9A | |
| SCHEMBL718625 | 0.69 | MAPK1 (0.65) | MAPK1MAPTPKMRAB9AKMT2A | |
| SCHEMBL3950396 | 0.69 | HCAR3 (0.57) | MAPK1MAPTLMNAPKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582681-A1 | PIPERIDINYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES | Novartis AG (CH) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011157793-A1 | PIPERIDINYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES | NOVARTIS AG (CH) | 2011-12-22 | — | — | WO | disclosed |