Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16827922 | 0.86 | MAPT (0.60) | HPGDSJAK2JAK1KDM4EALDH1A1 | |
| SCHEMBL16827990 | 0.82 | GPR119 (0.46) | JAK2JAK1KDM4EALDH1A1MAPT | |
| SCHEMBL16992212 | 0.79 | HCAR1 (0.46) | KDM4EALDH1A1MAPTTHRBHTT | |
| SCHEMBL26667052 | 0.79 | PDE4B (0.52) | HPGDSJAK2JAK1ALDH1A1HPGD | |
| SCHEMBL25343613 | 0.79 | PDE4B (0.52) | HPGDSJAK2JAK1ALDH1A1HPGD | |
| SCHEMBL12539534 | 0.78 | JAK2 (0.48) | HPGDSJAK2JAK1KDM4EALDH1A1 | |
| SCHEMBL8037259 | 0.78 | HPGDS (0.49) | HPGDSJAK2JAK1KDM4EALDH1A1 | |
| SCHEMBL1969566 | 0.78 | USP30 (0.50) | HPGDSJAK2JAK1TRPV3USP30 | |
| SCHEMBL7464833 | 0.77 | GPR119 (0.54) | HPGDSJAK2JAK1ALDH1A1HPGD | |
| SCHEMBL29806002 | 0.77 | USP30 (0.56) | JAK2JAK1MEN1KMT2AUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |