Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 6/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987433 | 0.85 | LTA4H (0.35) | LMNAALDH1A1KDM4EACACB | |
| SCHEMBL9988112 | 0.85 | LTA4H (0.36) | LMNAALDH1A1KDM4EACACB | |
| SCHEMBL973646 | 0.83 | CA12 (0.43) | KDM4EL3MBTL1 | |
| SCHEMBL9988123 | 0.81 | KDM4E (0.34) | KDM4EACACBCSNK2A2CSNK2A1 | |
| SCHEMBL9987651 | 0.81 | TSHR (0.40) | ALDH1A1TSHRKDM4EACACBL3MBTL1 | |
| SCHEMBL969683 | 0.72 | PIK3CD (0.39) | ALDH1A1 | |
| SCHEMBL974267 | 0.72 | LTA4H (0.33) | L3MBTL1MAPT | |
| SCHEMBL970374 | 0.71 | ACSS2 (0.35) | ALDH1A1HTTKDM4EL3MBTL1MAPT | |
| SCHEMBL9988118 | 0.71 | ACACB (0.38) | ACACB | |
| SCHEMBL971240 | 0.70 | TAAR1 (0.34) | MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582706-A1 | 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011157682-A1 | 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-22 | — | — | WO | disclosed |