Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987433 | 0.97 | LTA4H (0.35) | LTA4HALDH1A1LMNACA1CA2 | |
| SCHEMBL9987340 | 0.85 | LMNA (0.44) | ALDH1A1LMNAACACBKDM4E | |
| SCHEMBL974267 | 0.84 | LTA4H (0.33) | LTA4H | |
| SCHEMBL9987651 | 0.83 | TSHR (0.40) | ALDH1A1CA2ACACBKDM4ETDP1 | |
| SCHEMBL9988123 | 0.75 | KDM4E (0.34) | ACACBKDM4E | |
| SCHEMBL9987650 | 0.71 | MTNR1A (0.31) | — | |
| SCHEMBL969683 | 0.70 | PIK3CD (0.39) | ALDH1A1CA1CA2 | |
| SCHEMBL970374 | 0.69 | ACSS2 (0.35) | ALDH1A1KDM4ETDP1 | |
| SCHEMBL9988118 | 0.69 | ACACB (0.38) | ACACB | |
| SCHEMBL971469 | 0.67 | ALDH1A1 (0.40) | ALDH1A1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582706-A1 | 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011157682-A1 | 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-22 | — | — | WO | disclosed |