Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL971465 | 0.86 | ALDH1A1 (0.49) | KDM4EALDH1A1SMN1; SMN2GAAHSD17B10 | |
| SCHEMBL9987433 | 0.84 | LTA4H (0.35) | KDM4EALDH1A1ACACBCA2 | |
| SCHEMBL9988112 | 0.83 | LTA4H (0.36) | TDP1KDM4EALDH1A1ACACBCA2 | |
| SCHEMBL1068827 | 0.82 | ALDH1A1 (0.41) | TSHRTDP1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL9987340 | 0.81 | LMNA (0.44) | TSHRL3MBTL1KDM4EALDH1A1ACACB | |
| SCHEMBL9988123 | 0.79 | KDM4E (0.34) | KDM4EACACB | |
| SCHEMBL971469 | 0.78 | ALDH1A1 (0.40) | TDP1KDM4EALDH1A1 | |
| SCHEMBL9988118 | 0.75 | ACACB (0.38) | ACACB | |
| SCHEMBL9987440 | 0.74 | GPR119 (0.45) | TSHRACACB | |
| SCHEMBL9987655 | 0.72 | GPR119 (0.41) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582706-A1 | 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011157682-A1 | 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-22 | — | — | WO | disclosed |