SCHEMBL9987540

SCHEMBL9987540

CC(C)CNS(=O)(=O)c1cn[c]s1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.36
ATM Q13315 1/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35
LMNA P02545 1/20 0.34
TSHR P16473 2/20 0.33
ALOX5AP P20292 3/20 0.32
FEN1 P39748 3/20 0.32
CA1 P00915 3/20 0.31
CA2 P00918 3/20 0.31
GBA1 P04062 1/20 0.31
PDK1 Q15118 1/20 0.30
PDK2 Q15119 1/20 0.30
PDK3 Q15120 1/20 0.30
PDK4 Q16654 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL970863 0.78 HPGD (0.31) ALDH1A1KMT2AMEN1HPGD
SCHEMBL5200239 0.67 CYP2C9 (0.66) ALDH1A1ATMHPGDTSHR
SCHEMBL10267080 0.64 ALDH1A1 (0.43) ALDH1A1KMT2AMEN1ATMGAA
SCHEMBL3454929 0.62 MAPT (0.55) ALDH1A1KMT2AGAAHPGD
SCHEMBL2104884 0.62 ALDH1A1 (0.62) ALDH1A1KMT2AMEN1GAAHPGD
SCHEMBL7445356 0.61 ALDH1A1 (0.55) ALDH1A1KMT2AGAAHPGDLMNA
SCHEMBL674105 0.61 ALDH1A1 (0.66) ALDH1A1KMT2ALMNACA1CA2
Hydrochloric Acid SCHEMBL14638221 0.60 ALDH1A1 (0.64) ALDH1A1KMT2AGAAHPGDLMNA
SCHEMBL7862567 0.60 GBA1 (0.74) ALDH1A1KMT2AMEN1ATMGAA
SCHEMBL972819 0.59

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582706-A1 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS F.HOFFMANN-LA ROCHE AG (CH) 2013-04-24 EP disclosed
WO-2011157682-A1 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS F. HOFFMANN-LA ROCHE AG (CH) 2011-12-22 WO disclosed