Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | GBA1 | P04062 | 2/20 | 0.61 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.52 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14638221 | 0.98 | ALDH1A1 (0.64) | ALDH1A1GBA1PKMKMT2ATP53 | |
| SCHEMBL20021993 | 0.89 | ALDH1A1 (0.63) | ALDH1A1GBA1PKMKMT2AGRIA4 | |
| SCHEMBL6323680 | 0.85 | GBA1 (0.57) | ALDH1A1GBA1PKMKMT2ATP53 | |
| SCHEMBL174302 | 0.85 | GBA1 (0.57) | ALDH1A1GBA1PKMKMT2ATP53 | |
| SCHEMBL13508355 | 0.85 | GBA1 (0.57) | ALDH1A1GBA1PKMKMT2ATP53 | |
| SCHEMBL11649104 | 0.85 | GBA1 (0.72) | ALDH1A1GBA1PKMKMT2ATP53 | |
| SCHEMBL27478957 | 0.83 | GBA1 (0.56) | ALDH1A1GBA1PKMKMT2ATP53 | |
| SCHEMBL7862567 | 0.82 | GBA1 (0.74) | ALDH1A1GBA1KMT2ASMN1; SMN2CA1 | |
| SCHEMBL8279557 | 0.82 | GBA1 (0.63) | ALDH1A1GBA1PKMKMT2ATP53 | |
| SCHEMBL18680063 | 0.82 | GBA1 (0.54) | ALDH1A1GBA1PKMKMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245018-B1 | PROCESS FOR PREPARING BOSENTAN | GENERICS UK LTD (GB) | 2017-08-30 | — | — | EP | claimed |
| CN-104379559-B | Compound (I) | 葛兰素集团有限公司 | 2016-11-09 | — | — | CN | claimed |
| EP-2897970-B1 | MACROLIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2016-07-13 | — | — | EP | claimed |
| US-20150210729-A1 | MACROLIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2015-07-30 | — | — | US | claimed |
| EP-2897970-A1 | MACROLIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2015-07-29 | — | — | EP | claimed |
| EP-2841416-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2015-03-04 | — | — | EP | claimed |
| EP-2773637-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | Xenon Pharmaceuticals Inc. (CA) | 2014-09-10 | — | — | EP | claimed |
| EP-2760443-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE IN THE MODULATION RETINOID - RELATED ORPHAN RECEPTOR | Glaxo Group Limited (GB) | 2014-08-06 | — | — | EP | claimed |
| US-8785461-B2 | Process for preparing bosentan | GENERICS [UK] LIMITED (GB) | 2014-07-22 | — | — | US | claimed |
| WO-2014044645-A1 | MACROLIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2014-03-27 | — | — | WO | claimed |
| WO-2012024472-A1 | CHLORINE-FREE INK AND COATING COMPOSITIONS & A METHOD FOR PRINTING ON UNTREATED POLYOLEFIN FILMS WITH IMPROVED ADHESION | SUN CHEMICAL CORPORATION (US) | 2012-02-23 | — | — | WO | claimed |
| EP-2245018-A1 | PROCESS FOR PREPARING BOSENTAN | Generics [UK] Limited (GB) | 2010-11-03 | — | — | EP | claimed |
| US-20090227586-A1 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-10 | — | — | US | claimed |
| WO-2009098517-A1 | PROCESS FOR PREPARING BOSENTAN | GENERICS [UK] LIMITED (GB) | 2009-08-13 | — | — | WO | claimed |
| CN-101506175-A | 2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase C-alpha | BOEHRINGER INGELHEIM INT (DE) | 2009-08-12 | — | — | CN | claimed |
| EP-1976498-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-10-08 | — | — | EP | claimed |
| US-20070293494-A1 | 2-Anilino-4-(Heterocyclic) Amino-Pyrimidines | DJUNG JANE F | 2007-12-20 | — | — | US | claimed |
| WO-2007127505-A2 | USE OF SULFONAMIDE DERIVATIVES IN THE TREATMENT OF DISORDERS OF THE METABOLISM AND THE NERVOUS SYSTEM | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-08 | — | — | WO | claimed |
| EP-1165866-B1 | ABRASIVE FILAMENTS OF PLASTICIZED POLYAMIDES | DU PONT (US) | 2004-01-28 | — | — | EP | claimed |
| US-5437690-A | Using an n-alkyl aromatic sulfonamide as dye promoter in dyeing aromatic polyamides, polybenzimidazoles, polyimides | SPRINGS INDUSTRIES, INC. (US) | 1995-08-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210729-A1 | MACROLIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | PCSK9, CYP51A1, ABCB11 | ALDH1A1 2132/4885GBA1 249/4885PKM 849/4885 |
| US-20070293494-A1 | 2-Anilino-4-(Heterocyclic) Amino-Pyrimidines | PRKCA, PRKCG, PRKCH | ALDH1A1 4216/4885GBA1 4850/4885PKM 176/4885 |
| US-20090227586-A1 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES | PRKCA, PRKCG, PRKCH | ALDH1A1 4216/4885GBA1 4850/4885PKM 176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.