Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.41 |
| ▸ | ACACB | O00763 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987655 | 1.00 | GPR119 (0.41) | GPR119PIK3CDACACBJAK2JAK1 | |
| SCHEMBL9987440 | 0.95 | GPR119 (0.45) | GPR119PIK3CDACACBBRD4SCN9A | |
| SCHEMBL9988118 | 0.92 | ACACB (0.38) | GPR119PIK3CDACACBSCN9A | |
| SCHEMBL971612 | 0.83 | GPR119 (0.48) | GPR119PIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL970394 | 0.83 | GPR119 (0.48) | GPR119PIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL973169 | 0.78 | GPR119 (0.53) | GPR119 | |
| SCHEMBL971907 | 0.75 | GPR119 (0.43) | GPR119PIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL9987340 | 0.68 | LMNA (0.44) | ACACBBRD4 | |
| SCHEMBL19460883 | 0.68 | GPR119 (0.51) | GPR119JAK2JAK1 | |
| SCHEMBL4282720 | 0.67 | GPR119 (0.45) | GPR119PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582706-A1 | 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011157682-A1 | 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-22 | — | — | WO | disclosed |