Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 11/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16172624 | 0.82 | SYK (0.43) | XDHAAK1PDE3BPDE3ACYP3A4 | |
| SCHEMBL12180502 | 0.82 | SYK (0.43) | XDHAAK1PDE3BPDE3ACYP3A4 | |
| SCHEMBL15801234 | 0.80 | RXRA (0.39) | XDHAAK1PDE3BPDE3ACYP3A4 | |
| SCHEMBL9987923 | 0.80 | RXRA (0.40) | XDHAAK1PDE3BPDE3ACYP3A4 | |
| SCHEMBL2692879 | 0.79 | XDH (0.38) | XDHAAK1PDE3BPDE3ACYP3A4 | |
| SCHEMBL5050129 | 0.77 | KDM4E (0.44) | XDHAAK1CYP3A4 | |
| SCHEMBL11991676 | 0.71 | FDPS (0.46) | HPGDAPP | |
| SCHEMBL13400007 | 0.69 | FDPS (0.44) | HPGD | |
| SCHEMBL677526 | 0.68 | ALDH1A1 (0.56) | — | |
| SCHEMBL15473206 | 0.68 | XDH (0.47) | XDHAAK1PDE3BPDE3ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966156-B1 | NEW COMPOUNDS III | ASTRAZENECA AB (SE) | 2011-12-21 | — | — | EP | disclosed |