Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.47 |
| ▸ | CELA1 | Q9UNI1 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GGT1 | P19440 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CFD | P00746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8771737 | 0.82 | PTGS2 (0.48) | PTGS2KDM4EHSD17B10ALDH1A1ESR1 | |
| SCHEMBL9672920 | 0.75 | PTGS2 (0.46) | PTGS2KDM4EHSD17B10ALDH1A1ESR1 | |
| SCHEMBL10448930 | 0.73 | PREP (0.53) | PREPCELA1PTGS2KDM4EHSD17B10 | |
| SCHEMBL1452054 | 0.73 | PTGS2 (0.47) | PTGS2KDM4EHSD17B10ALDH1A1ESR1 | |
| SCHEMBL6176436 | 0.73 | PTGS2 (0.47) | PTGS2KDM4EHSD17B10ALDH1A1ESR1 | |
| SCHEMBL9671297 | 0.70 | PTGS2 (0.44) | PTGS2KDM4EHSD17B10ALDH1A1ESR1 | |
| SCHEMBL9987990 | 0.70 | ESR1 (0.42) | KDM4EHSD17B10ALDH1A1ESR1HPGD | |
| SCHEMBL830478 | 0.70 | PREP (0.54) | PREPCELA1PTGS2KDM4EHSD17B10 | |
| SCHEMBL4277462 | 0.70 | LMNA (0.45) | ALDH1A1TDP1CYP3A4LMNABACE1 | |
| SCHEMBL9672953 | 0.69 | PTGS2 (0.44) | PTGS2KDM4EHSD17B10ALDH1A1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | claimed |