Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607387 | 0.84 | ALDH1A1 (0.46) | ESR2ALOX5MMP3BCL2L1MEN1 | |
| SCHEMBL9988099 | 0.83 | TRPA1 (0.37) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL9650164 | 0.83 | NPC1 (0.35) | ALOX5BCL2L1MEN1KMT2AMAPT | |
| SCHEMBL16720201 | 0.83 | ALOX5 (0.45) | ALOX5MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6056277 | 0.81 | ABL1 (0.45) | ESR1ESR2ALOX5MMP3BCL2L1 | |
| SCHEMBL16720369 | 0.80 | MKNK1 (0.37) | ALOX5MAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL16720178 | 0.79 | QDPR (0.44) | MAPTALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL16719458 | 0.79 | KIF11 (0.47) | ALDH1A1HSD17B10NPC1RAB9APOLB | |
| SCHEMBL16720079 | 0.79 | HRH3 (0.45) | CA12CA2CA4CA5ACA14 | |
| SCHEMBL16719654 | 0.79 | KDM4E (0.47) | ESR2MEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | claimed |
| CN-101094844-A | Chroman derivatives, medicaments and use in therapy | NOVOGEN RES PTY LTD (AU) | 2007-12-26 | — | — | CN | claimed |
| JP-52095620-A | — | — | None | — | — | JP | disclosed |
| CN-116113414-A | Combination therapy | 梅制药公司 | 2023-05-12 | — | — | CN | disclosed |
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |
| JP-S5295620-A | BENZEL ALCOHOL DERIVATIVES | TANABE SEIYAKU CO LTD | 1977-08-11 | — | — | JP | disclosed |