Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glucametacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 20/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glucametacin SCHEMBL24511 | 0.91 | PTGS2 (0.72) | PTGS2 | |
| Glucametacin SCHEMBL27641193 | 0.91 | PTGS2 (0.72) | PTGS2 | |
| Glucametacin SCHEMBL5081097 | 0.91 | PTGS2 (0.72) | PTGS2 | |
| Glucametacin SCHEMBL30344903 | 0.91 | PTGS2 (0.72) | PTGS2 | |
| Indomethacin SCHEMBL8702320 | 0.85 | PTGS2 (0.80) | PTGS2 | |
| Indomethacin SCHEMBL8509782 | 0.83 | PTGS2 (0.74) | PTGS2 | |
| SCHEMBL5080287 | 0.81 | PLA2G2A (0.65) | PTGS2 | |
| SCHEMBL5080284 | 0.81 | PLA2G2A (0.65) | PTGS2 | |
| Indomethacin SCHEMBL10489921 | 0.80 | PTGS2 (0.86) | PTGS2 | |
| Indomethacin SCHEMBL9242800 | 0.80 | PTGS2 (0.74) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397140-A1 | Compositions and methods for treating or preventing glaucoma or progression thereof | BAUSCH & LOMB INCORPORATED (US) | 2011-12-21 | — | — | EP | disclosed |