Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.38 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | PLD2 | O14939 | 1/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.36 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9998330 | 0.87 | OPRM1 (0.44) | OPRM1OPRD1OPRK1OPRL1HSD17B10 | |
| SCHEMBL9998993 | 0.83 | OPRL1 (0.45) | OPRM1OPRD1OPRK1OPRL1HSD17B10 | |
| SCHEMBL10248464 | 0.83 | OPRK1 (0.51) | OPRM1OPRD1OPRK1OPRL1HSD17B10 | |
| SCHEMBL10248209 | 0.83 | OPRK1 (0.51) | OPRM1OPRD1OPRK1OPRL1HSD17B10 | |
| Toluene SCHEMBL318509 | 0.81 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1ENPP2 | |
| SCHEMBL318086 | 0.80 | OPRL1 (0.48) | OPRM1OPRD1OPRK1OPRL1HSD17B10 | |
| SCHEMBL318087 | 0.80 | OPRL1 (0.48) | OPRM1OPRD1OPRK1OPRL1HSD17B10 | |
| SCHEMBL318391 | 0.80 | OPRL1 (0.48) | OPRM1OPRD1OPRK1OPRL1HSD17B10 | |
| SCHEMBL318533 | 0.78 | OPRM1 (0.46) | OPRM1OPRD1OPRK1OPRL1HSD17B10 | |
| SCHEMBL318548 | 0.78 | OPRM1 (0.46) | OPRM1OPRD1OPRK1OPRL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582701-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011160084-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2011-12-22 | — | — | WO | disclosed |