Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 13/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9998873 | 0.86 | OPRM1 (0.42) | OPRL1OPRK1OPRD1OPRM1HSD17B10 | |
| SCHEMBL10248209 | 0.84 | OPRK1 (0.51) | OPRL1OPRK1OPRD1OPRM1HSD17B10 | |
| SCHEMBL10248464 | 0.84 | OPRK1 (0.51) | OPRL1OPRK1OPRD1OPRM1HSD17B10 | |
| SCHEMBL9998646 | 0.83 | OPRM1 (0.46) | OPRL1OPRK1OPRD1OPRM1HSD17B10 | |
| SCHEMBL318391 | 0.82 | OPRL1 (0.48) | OPRL1OPRK1OPRD1OPRM1HSD17B10 | |
| SCHEMBL318086 | 0.82 | OPRL1 (0.48) | OPRL1OPRK1OPRD1OPRM1HSD17B10 | |
| SCHEMBL318087 | 0.82 | OPRL1 (0.48) | OPRL1OPRK1OPRD1OPRM1HSD17B10 | |
| SCHEMBL9998330 | 0.81 | OPRM1 (0.44) | OPRL1OPRK1OPRD1OPRM1HSD17B10 | |
| SCHEMBL318533 | 0.79 | OPRM1 (0.46) | OPRL1OPRK1OPRD1OPRM1HSD17B10 | |
| SCHEMBL318548 | 0.79 | OPRM1 (0.46) | OPRL1OPRK1OPRD1OPRM1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582701-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011160084-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2011-12-22 | — | — | WO | disclosed |