Rifamexil

Rifamexil

SCHEMBL191882

CCN(CC)c1nc2c(s1)c1c(O)c3c(O)c(C)c4c(c32)C(=O)[C@@](C)(O/C=C/[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C(/C)C(=O)N1)O4

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB11 O95342 5/20 0.70
MAPT P10636 4/20 0.70
ABCC4 O15439 4/20 0.70
ABCC2 Q92887 4/20 0.70
TBXA2R P21731 3/20 0.70
GAA P10253 3/20 0.70
MAPK1 P28482 3/20 0.70
ABCC3 O15438 3/20 0.70
NR1I2 O75469 2/20 0.70
ADRB2 P07550 2/20 0.70
ADRB1 P08588 2/20 0.70
ADORA3 P0DMS8 2/20 0.70
ADRA2B P18089 2/20 0.70
ADRA2C P18825 2/20 0.70
SLC6A2 P23975 2/20 0.70
NPY1R P25929 2/20 0.70
HTR2C P28335 2/20 0.70
ADORA2A P29274 2/20 0.70
BDKRB2 P30411 2/20 0.70
AVPR2 P30518 2/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Rifamexil SCHEMBL30549418 1.00 ABCB11 (0.70) ABCB11MAPTABCC4ABCC2TBXA2R
SCHEMBL29885400 0.91 ABCB11 (0.72) ABCB11MAPTABCC4ABCC2TBXA2R
SCHEMBL29884731 0.87 ABCB11 (0.73) ABCB11MAPTABCC4ABCC2TBXA2R
SCHEMBL31447566 0.85 ABCB11 (0.83) ABCB11MAPTABCC4ABCC2TBXA2R
SCHEMBL29793694 0.85 ABCB11 (0.74) ABCB11MAPTABCC4ABCC2TBXA2R
SCHEMBL29702867 0.85 ABCB11 (0.74) ABCB11MAPTABCC4ABCC2TBXA2R
SCHEMBL29884612 0.84 ABCB11 (0.66) ABCB11MAPTABCC4ABCC2TBXA2R
SCHEMBL23359133 0.83 ABCB11 (0.76) ABCB11MAPTABCC4ABCC2TBXA2R
SCHEMBL31715785 0.83 ABCB11 (0.76) ABCB11MAPTABCC4ABCC2TBXA2R
SCHEMBL31715689 0.83 ABCB11 (0.76) ABCB11MAPTABCC4ABCC2TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1200 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220347108-A1 PROCESS FOR PRODUCING A PHARMACEUTICAL FORMULATION COMPRISING CRYSTALLINE AND AMORPHOUS FRACTIONS OF AN ACTIVE SUBSTANCE BAYER AKTIENGESELLSCHAFT (DE) 2022-11-03 US claimed
EP-4041201-A1 PROCESS FOR PRODUCING A PHARMACEUTICAL FORMULATION COMPRISING CRYSTALLINE AND AMORPHOUS FRACTIONS OF AN ACTIVE SUBSTANCE Bayer Aktiengesellschaft (DE) 2022-08-17 EP claimed
US-20220169680-A1 CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2022-06-02 US claimed
EP-3912989-A1 CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN Institute of Basic Medical Sciences Chinese Academy of Medical Sciences (CN) 2021-11-24 EP claimed
WO-2021069349-A1 PROCESS FOR PRODUCING A PHARMACEUTICAL FORMULATION COMPRISING CRYSTALLINE AND AMORPHOUS FRACTIONS OF AN ACTIVE SUBSTANCE BAYER AKTIENGESELLSCHAFT (DE) 2021-04-15 WO claimed
EP-3804702-A1 METHOD FOR PREPARING A PHARMACEUTICAL FORMULATION COMPRISING ACTIVE AGENT, POLYMER AND SURFACTANT Bayer AG (DE) 2021-04-14 EP claimed
EP-3804701-A1 METHOD FOR PREPARING A PHARMACEUTICAL FORMULATION COMPRISING CRYSTALLINE AND AMORPHOUS PORTIONS OF AN ACTIVE SUBSTANCE Bayer AG (DE) 2021-04-14 EP claimed
US-10377779-B2 Carbonate prodrugs and methods of using the same ACORDA THERAPEUTICS, INC. (US) 2019-08-13 US claimed
US-20180086778-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME NEUROGESX, INC. 2018-03-29 US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20070093462-A1 Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA 2007-04-26 US claimed
WO-2007044693-A2 MULTI-FUNCTIONAL IONIC LIQUID COMPOSITIONS THE UNIVERSITY OF ALABAMA (US) 2007-04-19 WO claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
EP-1578434-A2 METHODS AND COMPOSITIONS RELATING TO ISOLEUCINE BOROPROLINE COMPOUNDS Point Therapeutics, Inc. (US) 2005-09-28 EP claimed
US-20040131628-A1 Nucleic acids for the treatment of disorders associated with microorganisms BRATZLER ROBERT L (US) 2004-07-08 US claimed
US-20040077601-A1 Methods and compositions relating to isoleucine boroproline compounds POINT THERAPEUTICS, INC. 2004-04-22 US claimed
WO-2004004658-A2 METHODS AND COMPOSITIONS RELATING TO ISOLEUCINE BOROPROLINE COMPOUNDS POINT THERAPEUTICS, INC. (US) 2004-01-15 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070093462-A1 Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients SLC5A6, PNLIP, IPMK ABCB11 40/4885MAPT 4156/4885ABCC4 320/4885
US-10377779-B2 Carbonate prodrugs and methods of using the same CA6, CA7, CA4 ABCB11 941/4885MAPT 3060/4885ABCC4 1418/4885
US-20180086778-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME CA6, CA7, CA4 ABCB11 941/4885MAPT 3060/4885ABCC4 1418/4885
US-20040077601-A1 Methods and compositions relating to isoleucine boroproline compounds BCAT1, BCAT2, APOB ABCB11 173/4885MAPT 3727/4885ABCC4 3162/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.