ADCY3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2657749	0.81	8/20
SCHEMBL2658721	0.74	8/20
SCHEMBL2658383	0.63	8/20
SCHEMBL2657546	0.61	8/20
SCHEMBL2657983	0.60	8/20
SCHEMBL2657082	0.74	7/20
SCHEMBL2657077	0.60	7/20
SCHEMBL1919194	0.53	7/20
SCHEMBL2653753	0.51	7/20
SCHEMBL2654576	0.51	7/20
SCHEMBL2655409	0.51	7/20
SCHEMBL2655997	0.49	7/20
SCHEMBL2656673	0.49	7/20
SCHEMBL2657984	0.64	6/20
SCHEMBL2658531	0.60	6/20
SCHEMBL2653428	0.58	6/20
SCHEMBL2653879	0.57	6/20
SCHEMBL2657305	0.52	6/20
SCHEMBL2656182	0.52	6/20
SCHEMBL2658725	0.51	6/20

Clinical trials — most relevant to ADCY3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
Carbidopa-levodopa in Neovascular AMD	PHASE2	COMPLETED
PDE5 Inhibition for Obesity-Related Cardiometabolic Dysfunction	PHASE2	COMPLETED
Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease	PHASE2	ACTIVE_NOT_RECRUITING
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
PET Whole Body Biodistribution and Test Retest Bain Imaging Studies Using a Phosphodiesterase 4 Inhibitor (R)-[11C]Rolipram	PHASE1	COMPLETED
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses	PHASE1	UNKNOWN
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.	PHASE1	COMPLETED
Caffeine Efficacy in ADCY5-related Dyskinesia	nan	UNKNOWN
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia	nan	COMPLETED
Assessment of ADCY5-related Movement Disorders With Motion SENSors	nan	COMPLETED
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias	nan	COMPLETED
Stress and Treatment Response in Puerto Rican Children With Asthma	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.	nan	RECRUITING
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms	nan	UNKNOWN
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
PDE3B in Metabolic Regulation	nan	ENROLLING_BY_INVITATION
The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) in Episodic Migraine Patients	nan	COMPLETED
Insulin Detemir in Obesity Management	nan	ACTIVE_NOT_RECRUITING
Mechanisms for Individual Differences in Hypertension in Obstructive Sleep	nan	COMPLETED
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Study of the Genetic Factors Involved in Autism and Related Disorders	nan	RECRUITING
The Detection of Glaucoma Using Pupillography	nan	COMPLETED
Seven Year Update of Macular Degeneration Patients	nan	COMPLETED
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	nan	ENROLLING_BY_INVITATION

Related proteins — ESM-2 sequence neighbours (a ADCY3 binder may also engage these)

Protein	Name	Similarity
ADCY2	Adenylate cyclase type 2	1.000	landscape →
P26769	—	0.999	P26769 →
P21932	—	0.998	P21932 →
Q8VHH7	—	0.998	Q8VHH7 →
P97490	—	0.995	P97490 →
Q80TL1	—	0.995	Q80TL1 →
Q03343	—	0.993	Q03343 →
P30804	—	0.992	P30804 →
P19334	—	0.991	P19334 →
P32870	—	0.991	P32870 →
P40146	—	0.991	P40146 →
P40144	—	0.991	P40144 →
ADCY5	Adenylate cyclase type 5	0.990	landscape →
Q9GYQ4	—	0.990	Q9GYQ4 →
P51830	—	0.990	P51830 →
Q9VW60	—	0.989	Q9VW60 →
ADCY8	Adenylate cyclase type 8	0.989	landscape →
Q04400	—	0.989	Q04400 →
ADCY6	Adenylate cyclase type 6 (EC 4.6.1.1) (ATP py	0.989	landscape →
P26770	—	0.989	P26770 →
Q5BKX6	—	0.989	Q5BKX6 →
P0C550	—	0.989	P0C550 →
ADCY7	Adenylate cyclase type 7 (EC 4.6.1.1) (ATP py	0.988	landscape →
Q4X251	—	0.988	Q4X251 →
S4R2P9	—	0.988	S4R2P9 →
P51829	—	0.988	P51829 →
Q6R5A3	—	0.988	Q6R5A3 →
Q9R186	—	0.987	Q9R186 →
O54853	—	0.987	O54853 →
Q9DGG6	—	0.987	Q9DGG6 →