ATP1A3

Sodium/potassium-transporting ATPase subunit · P13637 · ATP1A3 on Sugi Atlas →

17,655 patent compounds predicted against ATP1A3, 10,160 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL475105	0.51	15/20
SCHEMBL475107	0.51	15/20
SCHEMBL1484406	0.65	14/20
SCHEMBL1483332	0.74	13/20
SCHEMBL1483335	0.74	13/20
Uzarin (SCHEMBL702463)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL702464)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL1652279)	0.92	12/20
Ramnodigin (SCHEMBL1812161)	0.84	12/20
Actodigin (SCHEMBL122586)	0.74	12/20
SCHEMBL1483283	0.66	12/20
SCHEMBL714901	0.63	12/20
SCHEMBL2258970	0.63	12/20
SCHEMBL2256038	0.61	12/20
SCHEMBL2256162	0.61	12/20
SCHEMBL2256169	0.61	12/20
SCHEMBL255971	0.60	12/20
SCHEMBL716452	0.60	12/20
SCHEMBL174232	0.59	12/20
SCHEMBL256803	0.59	12/20

Clinical trials — most relevant to ATP1A3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)	PHASE4	UNKNOWN
Renal Transplantation and Inhaled Anesthetic Sevoflurane (SEVOREIN)	PHASE3	COMPLETED
Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation	PHASE2/PHASE3	UNKNOWN
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor	PHASE2	COMPLETED
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)	PHASE2	RECRUITING
Pilot Study, Comparative, Single-center, Randomized, Crossover, Double-blind, Against Placebo, Testing the Effectiveness of Triheptanoin Oil in Alternating Hemiplegia of Childhood	PHASE2	COMPLETED
Natural History Study of ATP1A3-related Disease	nan	UNKNOWN
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks	nan	RECRUITING
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
Sodium Accumulation Study in Haemodialysis: Brain Study	nan	RECRUITING
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome	nan	RECRUITING
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Genetic and Environmental Determinants of Hypertension	nan	COMPLETED
Hydroxychloroquin (HCQ) in chILD of Genetic Defect	nan	COMPLETED
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED
Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development	nan	COMPLETED
The Role of Biomarkers in Inherited Cardiac Conditions	nan	WITHDRAWN
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Registry of Unexplained Cardiac Arrest	nan	COMPLETED
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
Hypertension in High School Students	nan	COMPLETED
Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies	nan	NOT_YET_RECRUITING
Genetic Causes and Clinical Features of Childhood Interstitial Lung Diseases in China	nan	COMPLETED
Genetic and Biohumoral Factors Involved in Menière's Disease and Their Correlation With Phenotypes	nan	RECRUITING
Double Blind Crossover Comparison of Diuretics in the Young	nan	UNKNOWN
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
Gene Study for Infantile Onset Diabetes	nan	UNKNOWN
Artificial Intelligence for the Prioritization of Genetic Background in Brugada Syndrome	nan	COMPLETED
Longitudinal Assessment of Atypical Tripeptidyl Peptidase 1 Enzyme Deficiency Patients	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ATP1A3 binder may also engage these)

Protein	Name	Similarity
Q08DA1	—	1.000	Q08DA1 →
Q9N0Z6	—	1.000	Q9N0Z6 →
P50997	—	1.000	P50997 →
P04074	—	1.000	P04074 →
ATP1A1	Sodium/potassium-transporting ATPase subunit alpha-1	1.000	landscape →
Q6PIC6	—	1.000	Q6PIC6 →
P06687	—	1.000	P06687 →
Q8VDN2	—	1.000	Q8VDN2 →
P05024	—	1.000	P05024 →
Q92123	—	1.000	Q92123 →
P06685	—	1.000	P06685 →
P18907	—	1.000	P18907 →
P25489	—	1.000	P25489 →
Q92030	—	1.000	Q92030 →
P30714	—	1.000	P30714 →
P05025	—	1.000	P05025 →
Q5RDR3	—	1.000	Q5RDR3 →
P58312	—	1.000	P58312 →
Q9YH26	—	1.000	Q9YH26 →
P24798	—	1.000	P24798 →
D2WKD8	—	1.000	D2WKD8 →
P09572	—	1.000	P09572 →
ATP1A2	Sodium/potassium-transporting ATPase subunit	1.000	landscape →
P28774	—	0.998	P28774 →
A2VDL6	—	0.998	A2VDL6 →
Q6RWA9	—	0.997	Q6RWA9 →
Q5RCD8	—	0.997	Q5RCD8 →
P13607	—	0.997	P13607 →
P06686	—	0.996	P06686 →
P24797	—	0.996	P24797 →