Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 11/20 | 0.66 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.62 |
| ▸ | NOS2 | P35228 | 2/20 | 0.57 |
| ▸ | NOS1 | P29475 | 2/20 | 0.57 |
| ▸ | NOS3 | P29474 | 1/20 | 0.57 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.49 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.49 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4955426 | 1.00 | BHMT (0.66) | BHMTBHMT2NOS2NOS1NOS3 | |
| SCHEMBL60520 | 1.00 | BHMT (0.66) | BHMTBHMT2NOS2NOS1NOS3 | |
| SCHEMBL18832133 | 0.94 | BHMT (0.69) | BHMTBHMT2NOS2NOS1NOS3 | |
| SCHEMBL17956289 | 0.93 | BHMT (0.58) | BHMTBHMT2NOS2NOS1NOS3 | |
| SCHEMBL11575012 | 0.93 | BHMT (0.70) | BHMTBHMT2NOS2NOS1NOS3 | |
| SCHEMBL18832139 | 0.93 | BHMT (0.70) | BHMTBHMT2NOS2NOS1NOS3 | |
| SCHEMBL18832141 | 0.93 | BHMT (0.70) | BHMTBHMT2NOS2NOS1NOS3 | |
| SCHEMBL2367840 | 0.93 | BHMT (0.70) | BHMTBHMT2NOS2NOS1NOS3 | |
| SCHEMBL18832137 | 0.93 | BHMT (0.70) | BHMTBHMT2NOS2NOS1NOS3 | |
| SCHEMBL2367837 | 0.93 | BHMT (0.70) | BHMTBHMT2NOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240065994-A1 | COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING DISEASES OR DISORDERS ASSOCIATED WITH PROTEIN MISFOLDING | NICHENAMETLA SAILENDRA NATH (US) | 2024-02-29 | — | — | US | claimed |
| US-20240065994-A1 | COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING DISEASES OR DISORDERS ASSOCIATED WITH PROTEIN MISFOLDING | NICHENAMETLA SAILENDRA NATH (US) | 2024-02-29 | — | — | US | disclosed |
| US-9920106-B2 | GLP-1 compounds | NOVO NORDISK A/S (DK) | 2018-03-20 | — | — | US | disclosed |
| US-9803180-B2 | S-adenosylmethionine (SAM) synthase variants for the synthesis of artificial cofactors | Leibniz-Institut für Pflanzenbiochemie Stiftung des öffentlichen Rechts (DE) | 2017-10-31 | — | — | US | disclosed |
| US-20170240870-A9 | S-ADENOSYLMETHIONINE (SAM) SYNTHASE VARIANTS FOR THE SYNTHESIS OF ARTIFICIAL COFACTORS | Leibniz-Institut für Pflanzenbiochemie Stiftung des öffentlichen Rechts (DE) | 2017-08-24 | — | — | US | disclosed |
| EP-3066197-B1 | S-ADENOSYLMETHIONINE (SAM) SYNTHASE VARIANTS FOR THE SYNTHESIS OF ARTIFICIAL COFACTORS | LEIBNIZ-INSTITUT FÜR PFLANZENBIOCHEMIE STIFTUNG DES OFFENTLICHEN RECHTS (DE) | 2017-08-16 | — | — | EP | disclosed |
| US-20160264946-A1 | S-ADENOSYLMETHIONINE (SAM) SYNTHASE VARIANTS FOR THE SYNTHESIS OF ARTIFICIAL COFACTORS | LEIBNIZ-INSTITUT FÜR PFLANZEN-BIOCHEMIE STIFTUNG DES ÖFFENTLICHEN RECHTS (DE) | 2016-09-15 | — | — | US | disclosed |
| EP-3066197-A1 | S-ADENOSYLMETHIONINE (SAM) SYNTHASE VARIANTS FOR THE SYNTHESIS OF ARTIFICIAL COFACTORS | Leibniz-Institut Für Pflanzenbiochemie Stiftung Des Offentlichen Rechts (DE) | 2016-09-14 | — | — | EP | disclosed |
| EP-2330126-B1 | Protracted exendin-4 compounds | NOVO NORDISK AS (DK) | 2015-12-23 | — | — | EP | disclosed |
| EP-1765408-B1 | POLYPEPTIDE PROTRACTING TAGS COMPRISING A TETRAZOLE MOIETY | NOVO NORDISK AS (DK) | 2015-12-09 | — | — | EP | disclosed |
| WO-2006087354-A2 | INSULINOTROPIC AGENTS CONJUGATED WITH STRUCTURALLY WELL DEFINED BRANCHED POLYMERS | NOVO NORDISK A/S (DK) | 2006-08-24 | — | — | WO | disclosed |
| EP-1667724-A2 | ALBUMIN-BINDING DERIVATIVES OF THERAPEUTIC PEPTIDES | NOVO NORDISK A/S (DK) | 2006-06-14 | — | — | EP | disclosed |
| WO-2006037811-A2 | PROTRACTED EXENDIN-4 COMPOUNDS | NOVO NORDISK A/S (DK) | 2006-04-13 | — | — | WO | disclosed |
| WO-2006005667-A2 | POLYPEPTIDE PROTRACTING TAGS COMPRISING A TETRAZOLE MOIETY | NOVO NORDISK A/S (DK) | 2006-01-19 | — | — | WO | disclosed |
| WO-2005093078-A1 | GENETICALLY MODIFIED PLANTS AND THEIR APPLICATIONS IN PHYTOREMEDIATION. | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2005-10-06 | — | — | WO | disclosed |
| WO-2005090583-A1 | GENETICALLY MODIFIED PLANTS AND THEIR APPLICATIONS IN PHYTOREMEDIATION. | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2005-09-29 | — | — | WO | disclosed |
| WO-2005058954-A1 | NOVEL GLP-1 COMPOUNDS | NOVO NORDISK A/S (DK) | 2005-06-30 | — | — | WO | disclosed |
| WO-2005058958-A2 | NOVEL GLP-1 ANALOGUES LINKED TO ALBUMIN-LIKE AGENTS | NOVO NORDISK A/S (DK) | 2005-06-30 | — | — | WO | disclosed |
| WO-2005028516-A2 | ALBUMIN-BINDING DERIVATIVES OF THERAPEUTIC PEPTIDES | NOVO NORDISK A/S (DK) | 2005-03-31 | — | — | WO | disclosed |
| US-5439803-A | Using label derived from isotopically substituted glucose to measure relative activities of glycolysis and the pentose phosphate pathway | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1995-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240065994-A1 | COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING DISEASES OR DISORDERS ASSOCIATED WITH PROTEIN MISFOLDING | HSPA5, TXN2, TXNRD1 | BHMT 127/4885BHMT2 207/4885NOS2 1765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.