CHD4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Dinaciclib (SCHEMBL12048446)	1.00	1/20
Dinaciclib (SCHEMBL15637863)	1.00	1/20
Dinaciclib (SCHEMBL23682977)	1.00	1/20
Dinaciclib (SCHEMBL30176832)	1.00	1/20
SCHEMBL15576865	0.86	1/20
SCHEMBL20366942	0.84	1/20
SCHEMBL23815646	0.84	1/20
SCHEMBL16366036	0.84	1/20
SCHEMBL12048531	0.83	1/20
SCHEMBL18738298	0.82	1/20
SCHEMBL12953008	0.81	1/20
SCHEMBL12953146	0.81	1/20
SCHEMBL12953641	0.81	1/20
SCHEMBL12954295	0.81	1/20
SCHEMBL13116917	0.81	1/20
SCHEMBL17898402	0.80	1/20
SCHEMBL14346166	0.79	1/20
SCHEMBL14346562	0.78	1/20
SCHEMBL14364529	0.78	1/20
SCHEMBL14276480	0.77	1/20

Clinical trials — most relevant to CHD4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Trial of the Histone-Deacetylase Inhibitor ITF2357 Followed by Mechlorethamine in Relapsed/Refractory Hodgkin's Lymphoma	PHASE1/PHASE2	COMPLETED
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS	PHASE2	COMPLETED
Evaluation of the Safety and the Tolerability of a Combination of Two HIV Inducers in Patients With Undetectable Viral Load	PHASE1	COMPLETED
Study of Cytolytic Viral Activation Therapy (CVAT) for Recurrent/Metastatic Nasopharyngeal Carcinoma	PHASE1	UNKNOWN
Investigation of the HDAC4 Copy Number Variation and Its Effect on Gene and Protein Expression in Patients With ASD	nan	COMPLETED
Global Profiling of Gene and Protein Expression Associated With Coronary Heart Disease Reversal	nan	COMPLETED
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients	nan	RECRUITING
UTHealth Turner Syndrome Research Registry	nan	RECRUITING
X-chromosome Inactivation, Epigenetics and the Transcriptome	nan	COMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics	nan	UNKNOWN
Research for Genetic Factors Involved in Congenital Dislocation of Hip: Genome-wide Association Study in Grand West France	nan	COMPLETED
Genetics of Congenital Heart Disease	nan	RECRUITING
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions	nan	RECRUITING
DNA Methylation and Autoimmune Thyroid Diseases	nan	COMPLETED
Accelerated Aging in Newborns and Adults With Congenital Heart Disease	nan	UNKNOWN
Clinical and Molecular Study of CHARGE Syndrom	nan	COMPLETED
Studying Genes in Samples From Younger Patients With Relapsed Acute Lymphoblastic Leukemia	nan	COMPLETED
The Sequencing for Detection in Congenital Heart Disease (SD-CHD) Study	nan	RECRUITING
Chromosomal Abnormalities in Patients With Congenital Heart Disease at Assiut University Children's Hospital	nan	NOT_YET_RECRUITING
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Family Resilience Initiative Research Program	nan	UNKNOWN
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study	nan	NOT_YET_RECRUITING
CMOP Regimen and Chidamide in the Treatment of Newly Diagnosed Peripheral T-cell Lymphoma	nan	UNKNOWN
Epigenomic Profiling of Circulating Cell-Free DNA (cfDNA) to Characterize the Dynamic Evolution of Molecular Subtypes in Extensive-Stage Small Cell Lung Cancer During First-Line Chemoimmunotherapy	nan	NOT_YET_RECRUITING
Risk Burden of Lipoprotein Metabolic Gene Haplotypes	nan	COMPLETED
Precision High-Intensity Training Through Epigenetics (PHITE)	nan	COMPLETED
dbGaP Protocol: The Pediatric Cardiac Genetics Consortium (PCGC)	nan	COMPLETED
Chromosome 18 Clinical Research Center	nan	RECRUITING
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CHD4 binder may also engage these)

Protein	Name	Similarity
Q6PDQ2	—	1.000	Q6PDQ2 →
A2A8L1	—	1.000	A2A8L1 →
Q8TDI0	—	1.000	Q8TDI0 →
D3ZD32	—	1.000	D3ZD32 →
CHD3	Chromodomain-helicase-DNA-binding protein 3	0.997	landscape →
D3ZA12	—	0.997	D3ZA12 →
A3KFM7	—	0.996	A3KFM7 →
Q8TD26	—	0.995	Q8TD26 →
O97159	—	0.993	O97159 →
Q9C813	—	0.992	Q9C813 →
Q03468	—	0.992	Q03468 →
DHX29	ATP-dependent RNA helicase DHX29	0.991	landscape →
Q9NEL2	—	0.991	Q9NEL2 →
Q22516	—	0.991	Q22516 →
B0R061	—	0.991	B0R061 →
B6ZLK2	—	0.991	B6ZLK2 →
E1B7X9	—	0.991	E1B7X9 →
Q96GQ7	—	0.991	Q96GQ7 →
KDM4B	Lysine-specific demethylase 4B	0.991	landscape →
G5EBZ4	—	0.991	G5EBZ4 →
BRPF3	Bromodomain and PHD finger-containing protein 3	0.990	landscape →
Q04692	—	0.990	Q04692 →
Q8WML3	—	0.990	Q8WML3 →
Q9Y4B4	—	0.990	Q9Y4B4 →
A7A0P8	—	0.990	A7A0P8 →
Q6PGC1	—	0.990	Q6PGC1 →
E7EZF3	—	0.990	E7EZF3 →
Q7G8Y3	—	0.990	Q7G8Y3 →
Q27746	—	0.989	Q27746 →
Q6P158	—	0.989	Q6P158 →