Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Baicalein. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.97 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 2/20 | 0.97 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 2/20 | 0.97 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.97 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.97 |
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.69 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.67 |
| ▸ | GSK3A known ✓ | P49840 | 1/20 | 0.67 |
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.67 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.97 |
| ▸ | PTPRS | Q13332 | 6/20 | 0.97 |
| ▸ | CREB1 | P16220 | 6/20 | 0.97 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.97 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.97 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.97 |
| ▸ | GABRP | O00591 | 3/20 | 0.97 |
| ▸ | GABRD | O14764 | 3/20 | 0.97 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.97 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Baicalein SCHEMBL139617 | 0.98 | ABCB1 (1.00) | ABCB1PTPRSCREB1CYP1A1KMT2A | |
| Baicalein SCHEMBL29385549 | 0.98 | ABCB1 (1.00) | ABCB1PTPRSCREB1CYP1A1KMT2A | |
| Baicalein SCHEMBL5695785 | 0.98 | ABCB1 (1.00) | ABCB1PTPRSCREB1CYP1A1KMT2A | |
| Baicalein SCHEMBL28630648 | 0.97 | ABCB1 (0.97) | ABCB1PTPRSCREB1CYP1A1KMT2A | |
| Baicalein SCHEMBL28198926 | 0.97 | ABCB1 (0.97) | ABCB1PTPRSCREB1CYP1A1KMT2A | |
| Baicalein SCHEMBL28372093 | 0.97 | ABCB1 (0.97) | ABCB1PTPRSCREB1CYP1A1KMT2A | |
| Baicalein SCHEMBL28087999 | 0.97 | ABCB1 (0.97) | ABCB1PTPRSCREB1CYP1A1KMT2A | |
| Baicalein SCHEMBL28826034 | 0.97 | ABCB1 (0.97) | ABCB1PTPRSCREB1CYP1A1KMT2A | |
| Baicalein SCHEMBL28206740 | 0.97 | ABCB1 (0.97) | ABCB1PTPRSCREB1CYP1A1KMT2A | |
| SCHEMBL8250407 | 0.95 | ABCB1 (0.94) | ABCB1PTPRSCREB1CYP1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114306631-B | Composite nano particle based on rice protein zymolyte and preparation method and application thereof | 齐鲁工业大学 | 2024-07-16 | — | — | CN | claimed |
| CN-114105930-A | Short rod-shaped MPN material based on coordination of baicalein and copper ions and preparation method and application thereof | 中国医学科学院基础医学研究所 | 2022-03-01 | — | — | CN | claimed |
| US-8673983-B2 | Melanins synthesized chemically or via enzyme catalysis | LOYOLA UNIVERSITY CHICAGO (US) | 2014-03-18 | — | — | US | claimed |
| US-20110230562-A1 | MELANINS SYNTHESIZED CHEMICALLY OR VIA ENZYME CATALYSIS | LOYOLA UNIVERSITY CHICAGO | 2011-09-22 | — | — | US | claimed |
| US-7365099-B2 | Reducing lipoxygenase activity by administering enzyme inhibitor | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-04-29 | — | — | US | claimed |
| US-20020197301-A1 | Animal body fat control | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2002-12-26 | — | — | US | claimed |
| CN-118754865-B | Baicalein derivative, preparation method thereof and application of baicalein derivative as pancreatic lipase inhibitor | 浙江析木生物科技有限公司 | 2025-06-17 | — | — | CN | disclosed |
| CN-118754865-A | Baicalein derivative, preparation method thereof and application of baicalein derivative as pancreatic lipase inhibitor | 浙江析木生物科技有限公司 | 2024-10-11 | — | — | CN | disclosed |
| CN-114105930-B | Short rod-shaped MPN material based on coordination of baicalein and copper ions, and preparation method and application thereof | 中国医学科学院基础医学研究所 | 2024-05-10 | — | — | CN | disclosed |
| CN-114105930-B | Short rod-shaped MPN material based on coordination of baicalein and copper ions, and preparation method and application thereof | 中国医学科学院基础医学研究所 | 2024-05-10 | — | — | CN | disclosed |
| CN-114105930-A | Short rod-shaped MPN material based on coordination of baicalein and copper ions and preparation method and application thereof | 中国医学科学院基础医学研究所 | 2022-03-01 | — | — | CN | disclosed |
| CN-114105930-A | Short rod-shaped MPN material based on coordination of baicalein and copper ions and preparation method and application thereof | 中国医学科学院基础医学研究所 | 2022-03-01 | — | — | CN | disclosed |
| CN-113304265-A | Hyaluronic acid baicalein iron nanoparticles and preparation method thereof | 重庆医科大学 | 2021-08-27 | — | — | CN | disclosed |
| US-20110230562-A1 | MELANINS SYNTHESIZED CHEMICALLY OR VIA ENZYME CATALYSIS | LOYOLA UNIVERSITY CHICAGO | 2011-09-22 | — | — | US | disclosed |
| US-7629400-B2 | Image making medium | HYMAN SYDNEY | 2009-12-08 | — | — | US | disclosed |
| WO-2009082735-A1 | MELANINS SYNTHESIZED CHEMICALLY OR VIA ENZYME CATALYSIS | UNIVERSITY OF CHICAGO (US) | 2009-07-02 | — | — | WO | disclosed |
| US-7365099-B2 | Reducing lipoxygenase activity by administering enzyme inhibitor | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-04-29 | — | — | US | disclosed |
| US-20040146539-A1 | Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits | GUPTA SHYAM K (US) | 2004-07-29 | — | — | US | disclosed |
| US-20030035917-A1 | Image making medium | HYMAN SYDNEY (US) | 2003-02-20 | — | — | US | disclosed |
| US-20020197301-A1 | Animal body fat control | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2002-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230562-A1 | MELANINS SYNTHESIZED CHEMICALLY OR VIA ENZYME CATALYSIS | TYR, TH, MAOA | MEN1 1492/4885HDAC8 3458/4885HDAC6 2346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.