SCHEMBL335753

SCHEMBL335753

CCOc1ccc(-n2c([C@@H](C)N(Cc3cccnc3)C(=O)Cc3ccc(OC(F)(F)F)cc3)nc3ncccc3c2=O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CXCR3 P49682 20/20 1.00
CYP3A4 P08684 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL433439 1.00 CXCR3 (1.00) CXCR3CYP3A4
SCHEMBL29386766 1.00 CXCR3 (1.00) CXCR3CYP3A4
SCHEMBL12857733 0.95 CXCR3 (1.00) CXCR3CYP3A4
SCHEMBL5833103 0.94 CXCR3 (0.89) CXCR3CYP3A4
SCHEMBL27015148 0.94 CXCR3 (0.89) CXCR3CYP3A4
SCHEMBL27015149 0.93 CXCR3 (0.87) CXCR3CYP3A4
SCHEMBL14960668 0.91 CXCR3 (1.00) CXCR3CYP3A4
SCHEMBL12857869 0.89 CXCR3 (1.00) CXCR3CYP3A4
SCHEMBL13770583 0.89 CXCR3 (1.00) CXCR3CYP3A4
SCHEMBL15064525 0.88 CXCR3 (1.00) CXCR3CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024238830-A2 TARGETING INFILTRATING CD8+ T CELLS IN ALZHEIMER'S DISEASE THE GENERAL HOSPITAL CORPORATION (US) 2024-11-21 WO claimed
CN-116144752-A Drug target spot for relieving intestinal epithelial cell structural damage, activating intestinal epithelial cell autophagy and/or reducing intestinal inflammation and application 华中农业大学 2023-05-23 CN claimed
US-20130172370-A1 PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF GLAUCOMA VT IDIRECT ,INC. (US) 2013-07-04 US claimed
CN-120114594-A Application of CXCL11 inhibitor in preparation of medicine for enhancing curative effect of PD-1/PD-L1 monoclonal antibody on treating hepatocellular carcinoma 大连医科大学 2025-06-10 CN disclosed
WO-2024238830-A2 TARGETING INFILTRATING CD8+ T CELLS IN ALZHEIMER'S DISEASE THE GENERAL HOSPITAL CORPORATION (US) 2024-11-21 WO disclosed
CN-118845785-A Application of CXCR3 inhibitor in treating myocardial hypertrophy and heart failure induced by immune checkpoint inhibitor 哈尔滨医科大学 2024-10-29 CN disclosed
US-20240016813-A1 METHODS OF TREATING SYMPTOMS OF CORONAVIRUS INFECTION Accencio LLC 2024-01-18 US disclosed
US-11857600-B2 GPCR heteromer inhibitors and uses thereof GPCR THERAPEUTICS, INC. (KR) 2024-01-02 US disclosed
US-20230321063-A1 COMPOSITIONS AND METHODS TO REDUCE NEUROINFLAMMATION SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) 2023-10-12 US disclosed
US-20230321063-A1 COMPOSITIONS AND METHODS TO REDUCE NEUROINFLAMMATION SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) 2023-10-12 US disclosed
US-20230321063-A1 COMPOSITIONS AND METHODS TO REDUCE NEUROINFLAMMATION SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) 2023-10-12 US disclosed
US-20090093451-A1 IL-8 Receptor Antagonists SMITHKLINE BEECHAM CORPORATION (US) 2009-04-09 US disclosed
US-20090093451-A1 IL-8 Receptor Antagonists SMITHKLINE BEECHAM CORPORATION (US) 2009-04-09 US disclosed
WO-2008070707-A1 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2008-06-12 WO disclosed
WO-2007150016-A2 IL-8 RECEPTOR ANTAGONIST SMITHKLINE BEECHAM CORPORATION (US) 2007-12-27 WO disclosed
WO-2007124424-A2 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2007-11-01 WO disclosed
WO-2007124423-A2 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2007-11-01 WO disclosed
US-20070249672-A1 IL-8 Receptor Antagonists GLAXOSMITHKLINE LLC 2007-10-25 US disclosed
US-20070249672-A1 IL-8 Receptor Antagonists GLAXOSMITHKLINE LLC 2007-10-25 US disclosed
US-20070249672-A1 IL-8 Receptor Antagonists GLAXOSMITHKLINE LLC 2007-10-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230321063-A1 COMPOSITIONS AND METHODS TO REDUCE NEUROINFLAMMATION CXCR3, MTOR, CX3CR1 CXCR3 1/4885CYP3A4 4721/4885
US-20070249672-A1 IL-8 Receptor Antagonists CXCL8, CCR8, IL1RN CXCR3 15/4885CYP3A4 3211/4885
US-20240016813-A1 METHODS OF TREATING SYMPTOMS OF CORONAVIRUS INFECTION ACE2, ACE, TMPRSS2 CXCR3 963/4885CYP3A4 1847/4885
US-20130172370-A1 PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF GLAUCOMA CXCR3, CCR5, CCR7 CXCR3 1/4885CYP3A4 3600/4885
US-20090093451-A1 IL-8 Receptor Antagonists CXCL8, CCR8, IL1RN CXCR3 15/4885CYP3A4 3211/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.