Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA2 | O43464 | 8/20 | 0.60 |
| ▸ | HTRA1 | Q92743 | 8/20 | 0.60 |
| ▸ | ALB | P02768 | 2/20 | 0.58 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.54 |
| ▸ | WDR5 | P61964 | 1/20 | 0.44 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22189219 | 1.00 | HTRA2 (0.60) | HTRA2HTRA1ALBFOLH1WDR5 | |
| SCHEMBL20661627 | 0.93 | ALB (0.56) | HTRA2HTRA1ALBFOLH1 | |
| SCHEMBL22189248 | 0.85 | FOLH1 (0.55) | HTRA2HTRA1ALBFOLH1SLC5A2 | |
| SCHEMBL22189249 | 0.85 | FOLH1 (0.55) | HTRA2HTRA1ALBFOLH1SLC5A2 | |
| SCHEMBL24943218 | 0.82 | ALB (0.59) | HTRA2HTRA1ALBFOLH1 | |
| SCHEMBL24062674 | 0.81 | ALB (0.59) | HTRA2HTRA1ALBFOLH1 | |
| SCHEMBL21766754 | 0.80 | HTRA2 (0.60) | HTRA2HTRA1ALBFOLH1WDR5 | |
| SCHEMBL18162918 | 0.79 | ALB (0.64) | HTRA2HTRA1ALBFOLH1 | |
| SCHEMBL23314226 | 0.79 | ALB (0.61) | HTRA2HTRA1ALBFOLH1WDR5 | |
| SCHEMBL24943566 | 0.78 | ALB (0.61) | HTRA2HTRA1ALBFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200215205-A1 | AN OSTEOADSORPTIVE FLUOROGENIC SUBSTRATE OF CATHEPSIN K FOR IMAGING OSTEOCLAST ACTIVITY AND MIGRATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200215205-A1 | AN OSTEOADSORPTIVE FLUOROGENIC SUBSTRATE OF CATHEPSIN K FOR IMAGING OSTEOCLAST ACTIVITY AND MIGRATION | CTSS, CTSK, CTSF | HTRA2 2322/4885HTRA1 926/4885ALB 4665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.