Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | ISG15 | P05161 | 1/20 | 0.45 |
| ▸ | USP5 | P45974 | 1/20 | 0.45 |
| ▸ | USP16 | Q9Y5T5 | 1/20 | 0.45 |
| ▸ | USP3 | Q9Y6I4 | 1/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13521724 | 0.84 | MAPT (0.49) | MAPTPOLBTP53HPGDHDAC6 | |
| SCHEMBL13521612 | 0.84 | MAPT (0.51) | MAPTPOLBTP53F2HPGD | |
| SCHEMBL3123200 | 0.83 | ADORA2B (0.39) | MAPTMAPK1TP53 | |
| SCHEMBL3118576 | 0.82 | CES2 (0.49) | MAPTPOLBTP53 | |
| SCHEMBL3129349 | 0.81 | GRIN1 (0.48) | F2GAA | |
| SCHEMBL3114848 | 0.81 | GRIN1 (0.43) | MAPTMAPK1TP53 | |
| SCHEMBL13521574 | 0.81 | TP53 (0.44) | MAPTTP53 | |
| SCHEMBL3131888 | 0.80 | HSD17B10 (0.49) | MAPTPOLBTP53 | |
| SCHEMBL3244764 | 0.79 | PKM (0.46) | MAPTPOLBHPGDTSHR | |
| SCHEMBL13521710 | 0.78 | GRIN1 (0.53) | POLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | claimed |