SCHEMBL2272471

SCHEMBL2272471

O=C(Nc1cc(/C=C/c2ccc(OC(F)(F)F)cc2)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IGF2BP2 Q9Y6M1 1/20 0.57
KCNK2 O95069 6/20 0.55
KCNK10 P57789 5/20 0.55
SNCA P37840 4/20 0.49
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
PKM P14618 2/20 0.49
MAPT P10636 1/20 0.49
GRIK1 P39086 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
PTPRC P08575 1/20 0.46
PTPN2 P17706 1/20 0.46
PTPN1 P18031 1/20 0.46
PTPN6 P29350 1/20 0.46
PTPN9 P43378 1/20 0.46
DUSP3 P51452 1/20 0.46
PTPN11 Q06124 1/20 0.46
PTPN22 Q9Y2R2 1/20 0.46
NPC1 O15118 1/20 0.46
MITF O75030 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2272483 1.00 IGF2BP2 (0.57) IGF2BP2KCNK2KCNK10SNCAMEN1
SCHEMBL2274101 0.88 SNCA (0.47) IGF2BP2KCNK2KCNK10SNCAMEN1
SCHEMBL2274106 0.88 SNCA (0.47) IGF2BP2KCNK2KCNK10SNCAMEN1
SCHEMBL27848573 0.87 IGF2BP2 (0.46) IGF2BP2KCNK2KCNK10SNCAMEN1
SCHEMBL5145301 0.86 TRPA1 (0.59) KCNK2KCNK10SNCAMEN1KMT2A
SCHEMBL5145298 0.86 TRPA1 (0.59) KCNK2KCNK10SNCAMEN1KMT2A
SCHEMBL2276655 0.85 PKM (0.62) SNCAMEN1KMT2APKMMAPT
SCHEMBL2276651 0.85 PKM (0.62) SNCAMEN1KMT2APKMMAPT
SCHEMBL2274009 0.85 IGF2BP2 (0.61) IGF2BP2KCNK2KCNK10MEN1KMT2A
SCHEMBL2273661 0.85 SNCA (0.68) KCNK2KCNK10SNCAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 IGF2BP2 4173/4885KCNK2 3527/4885KCNK10 2811/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.