Protegrin 1

Protegrin 1

SCHEMBL29352276

CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
F12 P00748 8/20 0.54
CXCR4 P61073 4/20 0.54
KCNMA1 Q12791 1/20 0.50
KCNMB4 Q86W47 1/20 0.50
CTSG P08311 2/20 0.50
KLK7 P49862 2/20 0.50
F11 P03951 2/20 0.49
F10 P00742 1/20 0.49
KLKB1 P03952 1/20 0.49
KLK1 P06870 1/20 0.49
KLK2 P20151 1/20 0.49
KLK14 Q9P0G3 1/20 0.49
KLK13 Q9UKR3 1/20 0.49
KLK5 Q9Y337 1/20 0.49
ST14 Q9Y5Y6 1/20 0.49
BECN1 Q14457 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29860724 0.97 F12 (0.52) F12CXCR4KCNMA1KCNMB4CTSG
SCHEMBL29389051 0.96 CTSG (0.51) F12CXCR4KCNMA1KCNMB4CTSG
Iseganan SCHEMBL29378977 0.93 CTSG (0.56) F12CXCR4KCNMA1KCNMB4CTSG
Iseganan SCHEMBL29420585 0.93 CTSG (0.55) F12CXCR4KCNMA1KCNMB4CTSG
SCHEMBL29388123 0.92 BECN1 (0.53) F12CXCR4CTSGKLK7F11
SCHEMBL29385556 0.91 CXCR4 (0.60) F12CXCR4KLKB1
Hydrochloric Acid SCHEMBL27846143 0.89 CTSG (0.54) CXCR4KCNMA1KCNMB4CTSGKLKB1
SCHEMBL29385468 0.87 KCNMA1 (0.57) F12KCNMA1KCNMB4KLKB1
SCHEMBL29352842 0.78 BECN1 (0.63) KCNMA1KCNMB4BECN1
Polyphemusin Ii SCHEMBL29449206 0.77 F12 (0.62) F12KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 326 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12377186-B2 Antimicrobial biopolymer compositions, methods of synthesis, and applications of use ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2025-08-05 US claimed
CN-116966267-A Antibacterial peptide nano polymer, preparation method and application 中国人民解放军空军军医大学 2023-10-31 CN claimed
US-20230270828-A1 COMPOSITION FOR USE IN THE TREATMENT OF VIRAL INFECTIONS BICT S.R.L. (IT) 2023-08-31 US claimed
US-11246819-B2 Compositions and methods for inhibiting biofilm deposition and production THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2022-02-15 US claimed
EP-3317293-B1 AN ANIMAL FEED OR ANIMAL FEED ADDITIVE COMPRISING ONE OR MORE POLYPEPTIDES HAVING LYSOZYME ACTIVITY AND USES THEREOF NOVOZYMES AS (DK) 2026-05-27 EP disclosed
WO-2026099341-A1 BIOCONTAINMENT OF UNWANTED ENGINEERED CELLS USING NON-NATURAL AMINO ACIDS SNIPR BIOME APS (DK) 2026-05-15 WO disclosed
EP-3937966-B1 COMPOSITIONS AND METHODS FOR PROTECTING TYPE 2 ALVEOLAR EPITHELIAL CELLS (AEC2) REIN THERAPEUTICS INC (US) 2026-05-06 EP disclosed
US-20260110698-A1 METHODS FOR QUANTIFYING FRATAXIN ACTIVITY LARIMAR THERAPEUTICS INC (US) 2026-04-23 US disclosed
US-20260108469-A1 COMPOSITIONS COMPRISING WATER INSOLUBLE DRUGS AND METHODS OF PRODUCING AND USING SAME NANO GHOST LTD (IL) 2026-04-23 US disclosed
US-12606640-B2 Recombinant antimicrobial multidomain polypeptide, methods of producing and uses thereof IRTA, INSTITUT DE RECERCA I TRANSFERÈNCIA AGROALIMENTÀRIES (ES) 2026-04-21 US disclosed
EP-4719450-A2 MODIFIED CAVEOLIN-1 PEPTIDE FORMULATIONS AND METHODS OF MANUFACTURING AND USE THEREOF Rein Therapeutics, Inc. (US) 2026-04-08 EP disclosed
EP-4712792-A1 A NOVEL FEED COMPOSITION DSM IP Assets B.V. (NL) 2026-03-25 EP disclosed
US-20220046954-A1 ANIMAL FEED COMPOSITION AND USE THEREOF NOVOZYMES A/S (DK) 2022-02-17 US disclosed
US-20220047685-A1 ANIMAL FEED COMPOSITION AND USE THEREOF NOVOZYMES A/S (DK) 2022-02-17 US disclosed
US-20220049230-A1 PHYTASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME NOVOZYMES A/S (DK) 2022-02-17 US disclosed
US-11246819-B2 Compositions and methods for inhibiting biofilm deposition and production THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2022-02-15 US disclosed
WO-2022029577-A1 COMPOSITION FOR USE IN THE TREATMENT OF VIRAL INFECTIONS BICT S.R.L. (IT) 2022-02-10 WO disclosed
US-11241476-B2 Mixtures and formulations comprising an alkyl ammonium EDTA salt CAMURUS AB (SE) 2022-02-08 US disclosed
US-11230575-B2 Insoluble fusion protein comprising antimicrobial peptide and method for producing antimicrobial peptide using same KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP (KR) 2022-01-25 US disclosed
US-11229223-B2 Enzyme granules for animal feed NOVOZYMES A/S (DK) 2022-01-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260108469-A1 COMPOSITIONS COMPRISING WATER INSOLUBLE DRUGS AND METHODS OF PRODUCING AND USING SAME ABCB1, WEE1, PARP3 F12 1341/4885CXCR4 297/4885KCNMA1 4815/4885
US-11246819-B2 Compositions and methods for inhibiting biofilm deposition and production ADAM33, FGB, ADAM17 F12 137/4885CXCR4 3331/4885KCNMA1 3180/4885
US-11241476-B2 Mixtures and formulations comprising an alkyl ammonium EDTA salt PHOSPHO1, LIPA, ABHD16A F12 63/4885CXCR4 3152/4885KCNMA1 478/4885
US-20260110698-A1 METHODS FOR QUANTIFYING FRATAXIN ACTIVITY ATXN2L, XDH, CYFIP1 F12 253/4885CXCR4 2394/4885KCNMA1 2046/4885
US-12606640-B2 Recombinant antimicrobial multidomain polypeptide, methods of producing and uses thereof SPPL2B, SPPL2A, LCT F12 1387/4885CXCR4 3213/4885KCNMA1 4585/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.