SCHEMBL8557

SCHEMBL8557

O=C1Nc2cc(Br)ccc2C1=O

nearest known ligand 0.71

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CES1 P23141 6/20 0.71
TGM2 P21980 6/20 0.71
MAOA P21397 6/20 0.55
MAOB P27338 6/20 0.55
BCHE P06276 1/20 0.52
S100A4 P26447 1/20 0.50
TDP2 O95551 1/20 0.46
KDR P35968 1/20 0.44
CMA1 P23946 1/20 0.44
AHR P35869 1/20 0.44
AGTR1 P30556 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nitrogen SCHEMBL29155979 0.96 CES1 (0.67) CES1TGM2MAOAMAOBBCHE
SCHEMBL19931150 0.87 TGM2 (0.59) CES1TGM2MAOAMAOBS100A4
SCHEMBL11920847 0.83 CES1 (0.50) CES1TGM2MAOAMAOBS100A4
SCHEMBL16668783 0.83 TGM2 (0.55) CES1TGM2MAOAMAOBS100A4
SCHEMBL13058804 0.83 TGM2 (0.55) CES1TGM2MAOAMAOBS100A4
SCHEMBL136581 0.83 TGM2 (1.00) CES1TGM2MAOAMAOBBCHE
SCHEMBL29505404 0.83 TGM2 (1.00) CES1TGM2MAOAMAOBBCHE
Methane SCHEMBL28522344 0.82 TGM2 (0.96) CES1TGM2MAOAMAOBBCHE
Water SCHEMBL8100148 0.82 TGM2 (0.96) CES1TGM2MAOAMAOBBCHE
SCHEMBL31107465 0.80 TGM2 (0.52) CES1TGM2MAOAMAOBS100A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 735 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119798230-A Indolone compounds and application thereof in treating acute and chronic liver diseases and promoting tissue repair 中国药科大学 2025-04-11 CN claimed
CN-118978509-A FAP receptor-targeted PET tracer and preparation method thereof 浙江大学 2024-11-19 CN claimed
CN-118530159-B Method for synthesizing 5-bromoisatin or 6-bromoisatin 山东仁一生物科技有限责任公司 2024-09-20 CN claimed
CN-118530159-A Method for synthesizing 5-bromoisatin or 6-bromoisatin 山东仁一生物科技有限责任公司 2024-08-23 CN claimed
CN-111574426-B Diamine monomer containing isoindigo structure and black polyimide synthesized by diamine monomer 湘潭大学 2023-06-23 CN claimed
CN-115716795-A Donor-acceptor type compound based on isoindigo derivative, preparation method, molecular lead and molecular electric switch 华东理工大学 2023-02-28 CN claimed
CN-114805325-A Multi-indolone Zig-Zag type bipolar small molecule and preparation method and application thereof 湖南工程学院 2022-07-29 CN claimed
CN-112500341-B Synthesis method of 7-hydroxyquinoline-4-carboxylic acid 苏州康润医药有限公司 2022-04-12 CN claimed
CN-113912609-A Preparation method of natural alkaloid tryptanthrin and derivative thereof 江苏大学 2022-01-11 CN claimed
CN-112708111-A Novel methoxyindophenine receptor and polymer, and preparation method and application thereof 中国科学院化学研究所 2021-04-27 CN claimed
CN-103524511-A Preparation method of 2,7,12-tribromo-5,10,15-trialkyltricarbazole UNIV NANJING POSTS & TELECOMM 2014-01-22 CN claimed
CN-102690226-A Multi-nitrogen substituted isatin derivative and synthetic method of multi-nitrogen substituted isatin derivative UNIV GUANGDONG TECHNOLOGY 2012-09-26 CN claimed
CN-102351777-A Preparation method for chiral 3-hydroxyl-3-methylene nitro indole-2-ketone derivative UNIV SOOCHOW 2012-02-15 CN claimed
US-20070130702-A1 Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative L'OREAL S.A. 2007-06-14 US claimed
US-7204857-B1 Dyeing method using a specific active methylene compound and a compound selected among a specific aldehyde, a specific ketone, a quinone and a di-imino-isoindoline or 3-amino-isoindolone derivative L'OREAL S.A. (FR) 2007-04-17 US claimed
EP-1139989-B1 AGENT FOR COLORING KERATINACEOUS FIBERS HENKEL KGAA (DE) 2006-10-18 EP claimed
US-6743263-B1 Method for coloring keratin fibers HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2004-06-01 US claimed
US-6635090-B1 Dyeing method using a specific cationic derivative and a compound selected among a specific aldehyde, a specific ketone, a quinone and a di-imino-isoindoline or 3-amino-isoindolone derivative L'OREAL, S.A. (FR) 2003-10-21 US claimed
US-6458168-B1 Hair dyeing method using an aliphatic cationic amine and compound chosen from an aldehyde, a ketone, a quinone, a di-imino-isoindoline, and a 3-aminoisoindolone derivative L'OREAL S.A. (FR) 2002-10-01 US claimed
US-6451067-B1 HAIR DYE MIXTURE L'OREAL S.A. (FR) 2002-09-17 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070130702-A1 Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative KRT18, NDUFB5, NDUFB7 CES1 3158/4885TGM2 1920/4885MAOA 467/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.