MT-ND3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
SCHEMBL8491443	0.56	4/20
SCHEMBL8489900	0.52	4/20
SCHEMBL8489907	0.52	4/20
SCHEMBL8492838	0.52	4/20
SCHEMBL8492845	0.52	4/20
SCHEMBL8489902	0.51	4/20
SCHEMBL8489908	0.51	4/20
SCHEMBL8491154	0.51	4/20
SCHEMBL8491160	0.51	4/20
SCHEMBL8491619	0.50	4/20
SCHEMBL8491624	0.50	4/20
SCHEMBL8491634	0.50	4/20
7-Prenyloxycoumarin (SCHEMBL4898255)	0.79	3/20
SCHEMBL712741	0.57	3/20
Geiparvarin (SCHEMBL2532495)	0.56	3/20
SCHEMBL6267768	0.55	3/20
SCHEMBL8493191	0.55	3/20
SCHEMBL8493327	0.55	3/20

Clinical trials — most relevant to MT-ND3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease	PHASE2	RECRUITING
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy	PHASE2	ACTIVE_NOT_RECRUITING
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)	PHASE1/PHASE2	NOT_YET_RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
The KHENEREXT Study	PHASE2	COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
MABs Therapy m.3243A>G Mutation Carriers	PHASE1	COMPLETED
Nicotinamide Riboside in LVAD Recipients	EARLY_PHASE1	COMPLETED
A Pilot Study to Examine the Effects of Vitamin D Supplementation on Mitochondrial Bioenergetics in Older Adults	EARLY_PHASE1	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
EPI-743 for Mitochondrial Respiratory Chain Diseases	nan	NO_LONGER_AVAILABLE
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Natural History Study - Mitochondrial Disease	nan	RECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Diagnostic Odyssey Survey 2	nan	COMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
Survey on Supplement Use in Mitochondrial Disease	nan	COMPLETED
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
Red Light Ptosis Proof-of-Concept	nan	UNKNOWN
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a MT-ND3 binder may also engage these)

Protein	Name	Similarity
Q9T9Y5	—	1.000	Q9T9Y5 →
Q9T9V8	—	0.999	Q9T9V8 →
O21604	—	0.999	O21604 →
Q5Y4Q3	—	0.998	Q5Y4Q3 →
O21546	—	0.998	O21546 →
Q38PR5	—	0.998	Q38PR5 →
O21598	—	0.997	O21598 →
Q2I3G7	—	0.997	Q2I3G7 →
Q96066	—	0.997	Q96066 →
Q9T9W7	—	0.995	Q9T9W7 →
O21575	—	0.995	O21575 →
P03899	—	0.995	P03899 →
Q9T9X5	—	0.995	Q9T9X5 →
O21540	—	0.995	O21540 →
O21332	—	0.994	O21332 →
P92482	—	0.994	P92482 →
Q95881	—	0.994	Q95881 →
O21616	—	0.994	O21616 →
P48654	—	0.994	P48654 →
Q9ZZ60	—	0.994	Q9ZZ60 →
Q95708	—	0.993	Q95708 →
Q3L6Y6	—	0.993	Q3L6Y6 →
Q95928	—	0.992	Q95928 →
Q2I3F4	—	0.992	Q2I3F4 →
A8DQI7	—	0.992	A8DQI7 →
O21513	—	0.992	O21513 →
O21543	—	0.991	O21543 →
O78753	—	0.991	O78753 →
O21519	—	0.991	O21519 →
Q8WAB4	—	0.991	Q8WAB4 →