NDUFA5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15258558	0.76	8/20
SCHEMBL12362713	0.77	7/20
SCHEMBL15080621	0.77	7/20
SCHEMBL12362702	0.73	7/20
SCHEMBL14351066	0.69	7/20
SCHEMBL12226742	0.61	7/20
SCHEMBL12362734	0.60	6/20
SCHEMBL12362700	0.57	6/20
SCHEMBL13973668	0.47	6/20
SCHEMBL16316892	0.47	6/20
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
SCHEMBL12362712	0.80	5/20
SCHEMBL14437596	0.57	5/20
SCHEMBL14437626	0.57	5/20
SCHEMBL14515244	0.57	5/20
SCHEMBL13743063	0.43	5/20
SCHEMBL11456503	0.71	4/20
SCHEMBL11456504	0.71	4/20
SCHEMBL11457189	0.69	4/20

Clinical trials — most relevant to NDUFA5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease	PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Effect of Montelukast Versus Co Enzyme in Sepsis	PHASE2/PHASE3	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy	PHASE2	ACTIVE_NOT_RECRUITING
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
Diagnostic Odyssey Survey 2	nan	COMPLETED
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Nicotinamide Riboside in Ulcerative Colitis	nan	RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Fasting Tolerance in MCADD-infants	nan	UNKNOWN
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NDUFA5 binder may also engage these)

Protein	Name	Similarity
Q0MQA2	—	1.000	Q0MQA2 →
Q0MQA1	—	1.000	Q0MQA1 →
P0CC00	—	1.000	P0CC00 →
Q63362	—	0.996	Q63362 →
P0CB99	—	0.996	P0CB99 →
Q4R5J1	—	0.992	Q4R5J1 →
Q9CPP6	—	0.991	Q9CPP6 →
P23935	—	0.991	P23935 →
Q9FLX7	—	0.983	Q9FLX7 →
Q5U5X0	—	0.962	Q5U5X0 →
Q9CQZ5	—	0.962	Q9CQZ5 →
Q02366	—	0.962	Q02366 →
Q0MQA4	—	0.960	Q0MQA4 →
NDUFA6	NADH dehydrogenase [ubiquinone] 1 alpha subco	0.959	landscape →
Q0MQA5	—	0.958	Q0MQA5 →
B4F7A1	—	0.958	B4F7A1 →
Q0MQA3	—	0.957	Q0MQA3 →
Q9DA03	—	0.957	Q9DA03 →
Q2M2S9	—	0.957	Q2M2S9 →
Q5REC3	—	0.956	Q5REC3 →
Q4WHK3	—	0.953	Q4WHK3 →
Q3T040	—	0.951	Q3T040 →
MRPS7	Small ribosomal subunit protein uS7m	0.951	landscape →
Q9NRP4	—	0.949	Q9NRP4 →
Q9LHI0	—	0.949	Q9LHI0 →
Q4IN52	—	0.949	Q4IN52 →
Q78RX3	—	0.949	Q78RX3 →
Q6TUF2	—	0.948	Q6TUF2 →
A0JPA6	—	0.948	A0JPA6 →
Q13084	—	0.948	Q13084 →