NDUFAF3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15258558	0.76	8/20
SCHEMBL12362713	0.77	7/20
SCHEMBL15080621	0.77	7/20
SCHEMBL12362702	0.73	7/20
SCHEMBL14351066	0.69	7/20
SCHEMBL12226742	0.61	7/20
SCHEMBL12362734	0.60	6/20
SCHEMBL12362700	0.57	6/20
SCHEMBL13973668	0.47	6/20
SCHEMBL16316892	0.47	6/20
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
Umbelliprenin (SCHEMBL18265478)	0.98	5/20
SCHEMBL12362712	0.80	5/20
SCHEMBL14437596	0.57	5/20
SCHEMBL14437626	0.57	5/20
SCHEMBL14515244	0.57	5/20
SCHEMBL13743063	0.43	5/20
SCHEMBL18197750	0.41	5/20
SCHEMBL18265492	0.74	4/20

Clinical trials — most relevant to NDUFAF3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease	PHASE2	RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)	PHASE1/PHASE2	NOT_YET_RECRUITING
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy	PHASE2	ACTIVE_NOT_RECRUITING
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Nicotinamide Riboside in LVAD Recipients	EARLY_PHASE1	COMPLETED
A Pilot Study to Examine the Effects of Vitamin D Supplementation on Mitochondrial Bioenergetics in Older Adults	EARLY_PHASE1	COMPLETED
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Diagnostic Odyssey Survey 2	nan	COMPLETED
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
EPI-743 for Mitochondrial Respiratory Chain Diseases	nan	NO_LONGER_AVAILABLE
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Cardiac Mitochondrial Function in Explanted Human Hearts	nan	UNKNOWN
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Nicotinamide Riboside in Ulcerative Colitis	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a NDUFAF3 binder may also engage these)

Protein	Name	Similarity
Q2HJI2	—	0.999	Q2HJI2 →
Q9JKL4	—	0.997	Q9JKL4 →
O08776	—	0.984	O08776 →
Q15526	—	0.948	Q15526 →
P82923	—	0.943	P82923 →
Q501J2	—	0.942	Q501J2 →
Q5EA03	—	0.938	Q5EA03 →
Q9BQD7	—	0.938	Q9BQD7 →
O97583	—	0.938	O97583 →
Q5I0I4	—	0.936	Q5I0I4 →
Q148G5	—	0.936	Q148G5 →
O43272	—	0.935	O43272 →
Q5RKZ7	—	0.935	Q5RKZ7 →
Q8VCE6	—	0.935	Q8VCE6 →
Q68EN5	—	0.935	Q68EN5 →
Q924T2	—	0.934	Q924T2 →
Q864R5	—	0.934	Q864R5 →
P53801	—	0.934	P53801 →
HDHD5	Haloacid dehalogenase-like hydrolase domain-containing 5	0.934	landscape →
P52850	—	0.934	P52850 →
Q5NVI6	—	0.934	Q5NVI6 →
Q7TSA0	—	0.933	Q7TSA0 →
A4K436	—	0.933	A4K436 →
RHOT2	Mitochondrial Rho GTPase 2	0.933	landscape →
Q5RE34	—	0.933	Q5RE34 →
Q8BNV1	—	0.933	Q8BNV1 →
Q9JJH7	—	0.933	Q9JJH7 →
PKN1	Serine/threonine-protein kinase N1	0.932	landscape →
Q8JZN7	—	0.932	Q8JZN7 →
Q6DFN1	—	0.932	Q6DFN1 →